From game-time decisions to injuries so significant they affect the value of every single position, let's break down the Fantasy and DFS impact of injuries for every Week 10 matchup. Know when to pivot and how your fantasy roster will be affected.
Below, you'll find a game-by-game look at the injuries you need to know that will have the biggest impact for Fantasy leagues, as well as the implications for DFS players. This week's list of notable names includes quarterbacks Josh Allen, Kyler Murray, Matthew Stafford and Ryan Tannehill; running backs Jonathan Taylor, Ezekiel Elliott and D'Andre Swift; receivers Adam Thielen, Mike Williams, Keenan Allen, and Mike Evans; tight ends Darren Waller and David Njoku; and many others, including key offensive line and defensive injuries to know.
- WR Marquise Goodwin (groin) - Questionable
- DE Poona Ford (illness) - Cleared
- NT Al Woods (illness) - Cleared
- S Ryan Neal (ankle) - Cleared
- WR Mike Evans (ribs) - Cleared
- WR Julio Jones (knee) - Cleared
- WR Russell Gage (hamstring) - Out
- TE Cameron Brate (neck) - Questionable
- OG Luke Goedeke (foot) - Out
- SS Antoine Winfield Jr. (concussion) - Cleared
The Seahawks are relatively healthy, facing a Tampa Bay defense that is has been inconsistent but is healthy heading into Sunday's game. Tampa Bay will be without Gage again, and the most significant news for the Bucs is the potential return of Cameron Brate. In Brate's absence, Cade Otton has been a low-end TE1. The Seahawks are an excellent matchup for tight ends and Otton is a solid streaming option if Brate is out.
There are no huge injury impacts in DFS for this early game. However, Otton is an excellent value play if Brate misses Week 10.
- WR Adam Thielen (ankle) - Cleared
- C Garrett Bradbury (ankle) - Cleared
- DT Dalvin Tomlinson (calf) - Out
- CB Cameron Dantzler (ankle) - Out
- QB Josh Allen (elbow) - Questionable
- OT Spencer Brown (ankle) - Cleared
- DE Greg Rousseau (ankle) - Out
- OLB Matt Milano (oblique) - Cleared
- MLB Tremaine Edmunds (groin) - Questionable
- CB Tre'Davious White (knee) - TBD
- CB Dane Jackson (neck) - Cleared
- CB Kaiir Elam (ankle) - Doubtful
- FS Jordan Poyer (elbow) - Out
After logging a limited practice on Friday, Josh Allen is questionable. Fantasy managers should monitor his status throughout the weekend and should add a backup option at quarterback, given the high number of quarterback injuries this week. Minnesota is a good matchup for the Buffalo pass game, but Fantasy managers should be wary of starting Gabe Davis and Isaiah McKenzie if Allen is out or plays through injury. Stefon Diggs is still a must-start in all formats. While the potential absence of Allen could boost opportunities for Devin Singletary, Minnesota has been strong against the run. Singletary is a flex option at best.
Case Keenum would get the start if Allen is out and Dawson Knox is someone who could see an increase in opportunities with Keenum at quarterback. Minnesota has given up the 11th most Fantasy points to opposing tight ends. Knox is only $3,300 on DraftKings.
- RB D'Andre Swift (ankle) - Cleared
- TB Craig Reynolds (ribs) - IR
- WR Josh Reynolds (back) - Out
- C Frank Ragnow (foot) - Cleared
- OLB Malcolm Rodriguez (elbow) - Questionable
- S Kerby Joseph (concussion) - Questionable
- G Teven Jenkins (hip) - Questionable
- DE Al-Quadin Muhammad (knee) - Doubtful
- CB Jaylon Johnson (oblique) - Questionable
- CB Kindle Vildor (ankle) - Out
Swift, who is cleared for Week 10, has been limited with injury concerns and his ceiling has been extremely low. It's difficult to trust Swift and fantasy managers should lean towards starting Jamaal Williams as an RB2 and utilize Swift as a flex option, unless we receive information over the weekend regarding an increase in snap count for Swift.
Although Swift is cleared, he should be avoided in DFS until is usage increases. The injury impact for DFS purposes is around Detroit receivers. With Reynolds out, Kalif Raymond will continue to see increased opportunities as a low-priced option at just $4,400 on DraftKings. Amon-Ra St. Brown continues to lead the way at is in play at just $6,900 in a game that could have high-scoring upside.
We are still waiting on more information on Engram's status. Engram has been a low-end TE1 on the season and Kansas City is an excellent matchup if he's active.
Hardman is out for Week 10 and his absence will have an interesting effect on the remaining receivers as he has averaged over 20 Fantasy points in PPR over the past three weeks. Hardman's absence could boost opportunities for Marquez Valdes-Scantling, making Valdes-Scantling a low-end flex option. While Fantasy managers may be tempted to start Kadarius Toney, Toney's snaps were very limited in his first game with the Chiefs, and he would be an extremely risky play.
McKinnon was a late addition to the injury report on Friday. The Chiefs' backfield has been poor from a Fantasy perspective but McKinnon has been the most productive back with his pass-catching upside. If McKinnon is absent, Clyde Edwards-Helaire and Isiah Pacheco could be deep league flex options.
Hardman has had three touchdowns in the past three weeks, and increased red-zone opportunities for Valdes-Scanting makes him a very appealing option at just $4,100 on DraftKings. While Pacheco would likely continue to lead the way on the ground for Kansas City, Fantasy value comes through receptions in the Chiefs backfield. If McKinnon is out, CEH would be a risky but interesting option at $5,800 on DraftKings.
- TE David Njoku (ankle) - Out
- OT Jack Conklin (foot) - Cleared
- OG Wyatt Teller (calf) - Cleared
- OLB Jeremiah Owusu-Koramoah (knee) - Out
- CB Greg Newsome II (oblique) - Cleared
- CB Martin Emerson (illness) - Cleared
- CB Denzel Ward (concussion) - Cleared
- WR River Cracraft (illness) - Cleared
- TE Durham Smythe (hamstring) - Cleared
- OT Terron Armstead (toe) - Questionable
- OL Austin Jackson (ankle, calf) - Questionable
- DT Raekwon Davis (knee) - Cleared
Njoku hoped to return but is officially inactive for Week 10. Harrison Bryant has underperformed in relief of Njoku and -- although the matchup against Miami is good -- Fantasy managers should find streaming options elsewhere.
The Browns' secondary has dealt with injuries all week but all CBs have been cleared for Week 10. Any limitations would benefit Tua Tagovailoa, Tyreek Hill and Jaylen Waddle. While the Miami triple-stack would be expensive, Cleveland has struggled on defense all season and this game should be a strong offensive play for Miami.
For the Browns offense, despite the absence of Njoku, Bryant is a low-upside option and should be avoided.
- RB Dameon Pierce (chest) - Cleared
- WR Brandin Cooks (wrist) - Questionable
- WR Nico Collins (groin) - Questionable
- DT Maliek Collins (chest) - Questionable
- WR Kenny Golladay (knee) - Questionable
- WR Richie James (concussion) - Cleared
- TE Daniel Bellinger (eye) - Out
- OT Evan Neal (knee) - Out
- OLB Oshane Ximines (quad) - Questionable
- FS Xavier McKinney (hand) - NFI
Pierce is cleared and a solid RB2 option this week. Fantasy managers must monitor status for Collins and Cooks throughout the weekend. The Texans' receiving corps has been unreliable and ineffective throughout the season. If both Cooks and Collins are active, it's difficult to trust either outside of a low-end flex option in deep leagues. However, if one is active with the other being injured, the healthy receiver becomes a flex option.
While Golladay is questionable and could return this week, there's no format where Golladay is a viable start.
Similar to season-long recommendations, neither Texans receiver is viable if both are active. Cooks is unappealing in any scenario but Collins is mildly interesting at just $4,000. If Collins is active and Cooks is out, Collins would operate at the WR1 at an extremely cheap price – if he has no limitations.
- RB Mark Ingram (knee) - Out
- WR Jarvis Landry (ankle) - Cleared
- C Erik McCoy (shoulder) - Out
- OG Andrus Peat (triceps) - Out
- DE Marcus Davenport (calf) - Questionable
- LB Pete Werner (ankle) - Out
- CB Marshon Lattimore (abdomen) - Out
- S Marcus Maye (abdomen) - Questionable
- S P.J. Williams (illness) - Questionable
- K Chris Boswell (groin) - IR
- DT Larry Ogunjobi (knee) - Cleared
- OLB T.J. Watt (knee) - TBD
- ILB Myles Jack (knee) - Cleared
- CB Ahkello Witherspoon (hamstring) - Out
- CB William Jackson (back) - Out
While we don't have final confirmation that Watt will be officially active, he told reporters he plans to play this week. Watt will be a welcome return to the Pittsburgh defense and could make things a little more difficult for Andy Dalton and the New Orleans weapons.
The Saints defense, which is typically strong, is dealing with significant injuries. It's still difficult to trust the Steelers running backs as Jaylen Warren is slated for increase opportunities and Najee Harris' role could suffer. Both running backs are in RB3 or low-end flex territory. The injury to Lattimore could open up opportunities for George Pickens in the Steelers' first game without Chase Claypool.
With the Saints' defensive injuries, Pickens at just $5,000 on DraftKings is an interesting option. The only other potential impact is around the Pittsburgh backfield. Harris has shown zero upside but Warren has looked electric when on the field. It's a risky play but if Warren sees a significant jump in snap count this week, he could pay off at $4,900.
While the return of Watt would be a huge boost to Pittsburgh, Alvin Kamara and Chris Olave are still viable options in DFS.
- WR K.J. Hamler (hamstring) - Out
- OT Cameron Fleming (quadriceps) - Questionable
- OLB Baron Browning (hip) - Out
- FS Justin Simmons (knee) - Questionable
- QB Ryan Tannehill (ankle) - Question
- RB Dontrell Hilliard (groin) - Cleared
- WR Treylon Burks (toe) - TBD
- OG Aaron Brewer (toe) - Cleared
- DT Teair Tart (illness) - Cleared
- ILB David Long (knee) - Cleared
- ILB Zach Cunningham (elbow) - Out
- OLB Bud Dupree (hip) - Out
- SS Amani Hooker (shoulder) - Out
- CB Kristian Fulton (hamstring) - Questionable
While the Titans are beat up on defense, it's difficult to trust any Broncos running back with the addition of Chase Edmonds, who will likely serve as the third-down back. Jerry Jeudy is the most reliable option in this offense and Coutland Sutton is a flex option.
Tannehill is still questionable but while the Titans are likely looking forward to his return, it has very little impact from a Fantasy perspective. Titans receivers should still be on every Fantasy manager's bench. The only playable option is Derrick Henry.
There is no significant DFS injury impact in this matchup. Options on both sides are risky and unreliable outside of Derrick Henry.
- QB Matt Ryan (shoulder) - TBD
- RB Jonathan Taylor (ankle) - Cleared
- RB Deon Jackson (knee) - Out
- TE Mo Alie-Cox (ankle) - Questionable
- TE Jelani Woods (shoulder) - Out
- OLB Shaquille Leonard (back) - IR
- WR Hunter Renfrow (oblique) - IR
- TE Darren Waller (hamstring) - IR
- LB Divine Deablo (back) - IR
- MLB Denzel Perryman (hip) - Questionable
Taylor is cleared to play in Week 10, and the backfield should solely belong to him with Deon Jackson out. The Colts could be down to just one tight end – Kylen Granson. However, the combination of Sam Ehlinger, new Colts interim head coach Jeff Saturday, and general team chaos makes if difficult to trust any Colts player outside of Taylor.
The Raiders placed Darren Waller and Hunter Refrow on IR this week. This should continue to open up opportunities for Mack Hollins as the team's second look in the pass game behind Davante Adams.
Although Taylor returns to action, he's a risky play in DFS. For the Raiders, targets will likely stay strong for Adams, who is the fourth highest-priced receiver on the main slate. Hollins is a value play at just $4,200.
- RB Ezekiel Elliott (knee) - Questionable
- WR Noah Brown (foot) - Cleared
- TE Jake Ferguson (illness) - Cleared
- FS Donovan Wilson (teeth) - Cleared
- OLB Anthony Barr (hamstring) - Out
- QB Aaron Rodgers (thumb) - Cleared
- RB Aaron Jones (ankle) - Cleared
- WR Allen Lazard (shoulder) - Cleared
- WR Sammy Watkins (knee) - Cleared
- WR Romeo Doubs (ankle) - Out
- WR Amari Rodgers (quad) - Questionable
- OG Elgton Jenkins (knee) - Cleared
- OT David Bakhtiari (knee) - Questionable
- K Mason Crosby (back) - Cleared
- OLB Preston Smith (shoulder) - Cleared
- ILB De'Vondre Campbell (knee) - Out
- OLB Rashan Gary (knee) - IR
- CB Eric Stokes (ankle) - Out
- CB Rasul Douglas (calf) - Cleared
The Packers have an extremely long list of injuries with Aaron Jones being the most notable. Jones exited Week 9 with an ankle injury and but is cleared for Week 10. Even in a difficult matchup Jones is a low-end RB1 with his pass-catching upside. The Packers are without Romeo Dobbs due to a high ankle sprain suffered last week, Sammy Watkins is questionable, and Amari Rodgers is questionable. Allen Lazard will continue to serve as the clear WR1 for the Packers and Robert Tonyan should see a boost in opportunities as well.
Defensively, the Packers lost Gary for the remainder of the season. This is a huge blow to an already struggling defense and increases opportunities for Dallas offensive players. Fantasy managers will need to monitor Elliott's status throughout the weekend. If he's inactive, Tony Pollard is a must start in all formats. Given the matchup, Pollard is still in RB2 even if Elliott is active. It's difficult to trust Elliott and Fantasy managers should avoid starting him unless we have specific confirmation regarding his snap count.
Dallas is a tough defensive draw but injuries to the Packers receivers place Lazard and Jones in a prime spot for increased targets at very reasonable prices, particular Lazard at just $6,100. Tony Pollard is priced up to $6,500 but would be a big play if Elliott is out.
- QB Kyler Murray (hamstring) - Questionable
- WR Greg Dortch (groin) - Questionable
- OT Cody Ford (illness) - Questionable
- OT Kelvin Beachum (illness) - Cleared
- OT D.J. Humphries (back) - Questionable
- C Rodney Hudson (knee) - Out
- OG Max Garcia (shoulder) - Out
- K Matt Prater (hip) - Questionable
- DE J.J. Watt (knee) - Cleared
- LB Dennis Gardeck (ankle) - Questionable
- S Budda Baker (ankle) - Questionable
- CB Byron Murphy (back) - Questionable
- QB Matthew Stafford (concussion) - Questionable
- RB Malcolm Brown (hamstring) - Out
- RB Kyren Williams (ankle) - TBD
- C Brian Allen (knee) - Questionable
- NT Greg Gaines (elbow) - Doubtful
- OG Alaric Jackson (knee) - Doubtful
Kliff Kingsbury announced Murray will be a gametime decision. This is critical because Arizona plays in the afternoon. Fantasy managers who wait for Kyler Murray's status will only have the option to pivot directly to Colt McCoy or stream Jimmy Garoppolo or Taylor Heinicke. This is critical because Stafford is also questionable for Sunday and in concussion protocol. Streaming options could be a hot commodity this week.
For the Rams, Stafford entered concussion protocol midweek and his status should be monitored throughout the weekend. However, the timing makes pivoting to another streaming option difficult and the matchup is not ideal if Stafford plays. Rather than waiting, Fantasy managers should find another option immediately. If Stafford is out, Cooper Kupp is the only reliable option in the Rams' offense.
Sean McVay confirmed Kyren Williams will be active on Sunday. The Rams backfield was already unusable, and all Rams running backs should be avoided. The Cardinals are dealing with significant injuries on defense but the Rams offense has struggled all season long.
Despite injuries across the board for both teams, there are no solid injury pivots within the game. Healthy, top options such as Kupp and DeAndre Hopkins are the only high-upside options in DFS.
- WR Mike Williams (ankle) - Out
- WR Keenan Allen (hamstring) - Out
- TE Tre' McKitty (hamstring) - Cleared
- K Dustin Hopkins (hamstring) - Out
- OT Trey Pipkins (knee) - Questionable
- RB Elijah Mitchell (knee) - TBD
- WR Deebo Samuel (hamstring) - Cleared
- DE Samson Ebukam (quadriceps) - Doubtful
- DT Arik Armstead (foot) - Out
- LB Dre Greenlaw (calf) - Cleared
The Chargers are without Williams and Allen in Week 10. Josh Palmer is a WR2 even in a difficult matchup against San Francisco. DeAndre Carter is a low-end flex option, while Michael Bandy is a deep-league option with limited upside.
The 49ers activated Elijah Mitchell from IR and he will likely serve as the backup to Christian McCaffrey. Deebo Samuel is cleared and set to return as well. Samuel's return could affect Brandon Aiyuk but given the Chargers overall defensive struggles, Aiyuk is still a flex option.
All Chargers receivers are value-priced for the showdown slate and solid options.
- RB J.D. McKissic (neck) - TBD
- WR Jahan Dotson (hamstring) - TBD
- C Tyler Larsen (back) - TBD
- LB Cole Holcomb (foot) - TBD
- DE Chase Young (knee) - TBD
- CB Avonte Maddox (hamstring) - TBD
Washington has two potential injury impacts this week. The potential absence of McKissic makes Gibson a low-end flex option. Gibson underwhelmed in Week 9, following two solid outings. However, Minnesota was a tough defensive matchup and this week could be a bounce back opportunity for Gibson. Jahan Dotson could return to action this week as well. Dotson had four touchdowns in his first four games of the season before suffering an injury that has kept him out for five weeks. His return could limit upside for Terry McLaurin and Curtis Samuel.
If McKissic is out, Gibson is a solid value play in the showdown with increased pass-catching upside if Washington plays from behind.