NFL Week 16 wraps up with Justin Herbert and the Los Angeles Chargers traveling to take on Nick Foles and the Indianapolis Colts on Monday Night Football at Lucas Oil Stadium. Both teams will be missing some star power with Jonathan Taylor and Joey Bosa both on Injured Reserve. The latest Chargers vs. Colts odds suggest that this MNF game could be a high-scoring affair with an over/under of 45.5 points, making it imperative to hit on the right mix of players from the MNF NFL DFS player pool when building your MNF NFL DFS strategy. Given his status as one of the top all-purpose running backs in the NFL, should Austin Ekeler be considered a must-start player in your NFL DFS lineups and NFL DFS stacks on Monday Night Football? Or should you build your MNF DFS rosters around Herbert, Keenan Allen, Mike Williams, Josh Palmer, Gerald Everett, Cameron Dicker, Michael Pittman Jr., Deon Jackson, or Zack Moss?

Before making any NFL DFS picks for Colts vs. Chargers on sites like DraftKings and FanDuel, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who has been cashing big all season, has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.

Kaylor has been spot-on all season, hitting on epic NFL DFS picks like Jerry Jeudy (4-102-1), Stefon Diggs (12-148-3, 6-106-1, 7-92-1), Amari Cooper (7-101-1, 5-131-1), Nick Chubb (23-113-1, 23-101-2), CeeDee Lamb (8-87-1), Deebo Samuel (6-115-1) Cooper Kupp (14-122), Travis Kelce (7-25-4, 10-106), Davante Adams (3-124-2), Justin Fields (179-1-1, 82-1), Derrick Henry (132-2), Jimmy Garoppolo (228-4), Michael Pittman (7-61-1), Christian McCaffrey (26-108-1, 6-30), Kirk Cousins (460-4), Justin Jefferson (12-123-1), J.K. Dobbins (13-125), and T.J. Hockenson (13-109-2). Anyone who has followed his picks is way up.

Now, Kaylor has turned his attention to Chargers vs. Colts on Monday Night Football Week 16 and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.

Top NFL DFS picks for Chargers vs. Colts on MNF

One of Kaylor's top DFS picks for the Colts vs. Chargers MNF game is Los Angeles quarterback Justin Herbert. The third-year pro out of Oregon has cleared 310 passing yards in his last three games, and has the Chargers in a position where they can clinch a playoff spot with a win on Monday night, making this an ideal spot for him to make it four straight. Indianapolis gave up 460 yards and four touchdowns to Kirk Cousins last week, and Kaylor is expecting Herbert to play at a level that justifies his price tag on Monday night.

"Justin Herbert has had an up-and-down season, but, outside of a below average performance against the Titans last week, the former Oregon star has been playing his best football of the season over the last month," Herbert told SportsLine. "With a playoff spot on the line, I am going expecting Herbert to shine during prime time on Monday Night Football. The Colts have a solid defense, but I am expecting the Chargers to put the game in Herbert's hands and let him carry them to the postseason. I am projecting around 300 yards and two passing touchdowns with 20-plus rushing yards for Herbert on MNF," Kaylor told SportsLine. You can see the rest of Kaylor's NFL DFS picks here.

How to build NFL DFS lineups for Colts vs. Chargers on MNF

Kaylor is also targeting another undervalued player who could explode for huge numbers for Monday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of Kaylor's MNF DFS picks, at SportsLine

So who is Jimmie Kaylor including in his optimal NFL DFS lineups for Monday Night Football? And which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a DFS expert who already won a single-game millionaire maker tournament in 2022, and find out.