Offense
| NO | Player | POS | HT | WT | DOB (AGE) | EXP | College |
|---|---|---|---|---|---|---|---|
| 17 | B. AllenBrandon Allen | QB | 6-2 | 209 | 9/5/1992 (31) | 7 | Arkansas |
| 14 | S. DarnoldSam Darnold | QB | 6-3 | 225 | 6/5/1997 (26) | 6 | USC |
| 13 | B. PurdyBrock Purdy | QB | 6-1 | 220 | 12/27/1999 (23) | 2 | Iowa St. |
| 32 | T. Davis-PriceTyrion Davis-Price | RB | 6-1 | 219 | 10/23/2000 (22) | 2 | LSU |
| 24 | J. MasonJordan Mason | RB | 5-11 | 223 | 5/24/1999 (24) | 2 | Georgia Tech |
| 23 | C. McCaffreyChristian McCaffrey | RB | 5-11 | 210 | 6/7/1996 (27) | 7 | Stanford |
| 25 | E. MitchellElijah Mitchell | RB | 5-10 | 200 | 5/2/1998 (25) | 3 | Louisiana |
| 44 | K. JuszczykKyle Juszczyk | FB | 6-2 | 235 | 4/23/1991 (32) | 11 | Harvard |
| 11 | B. AiyukBrandon Aiyuk | WR | 6-0 | 200 | 3/17/1998 (25) | 4 | Arizona St. |
| 10 | R. BellRonnie Bell | WR | 6-0 | 190 | 1/28/2000 (23) | R | Michigan |
| 15 | J. JenningsJauan Jennings | WR | 6-3 | 212 | 7/10/1997 (26) | 3 | Tennessee |
| 3 | R. McCloudRay-Ray McCloud | WR | 5-9 | 190 | 10/15/1996 (26) | 6 | Clemson |
| 19 | D. SamuelDeebo Samuel | WR | 6-0 | 215 | 1/15/1996 (27) | 5 | South Carolina |
| 82 | R. DwelleyRoss Dwelley | TE | 6-5 | 235 | 1/26/1995 (28) | 6 | San Diego |
| 85 | G. KittleGeorge Kittle | TE | 6-4 | 250 | 10/9/1993 (29) | 7 | Iowa |
| 9 | B. WillisBrayden Willis | TE | 6-4 | 240 | 11/11/1999 (23) | R | Oklahoma |
| 89 | C. WoernerCharlie Woerner | TE | 6-5 | 241 | 10/16/1997 (25) | 4 | Georgia |
| 64 | J. BrendelJake Brendel | C | 6-4 | 299 | 9/10/1992 (31) | 7 | UCLA |
| 55 | J. FelicianoJon Feliciano | C | 6-4 | 325 | 2/10/1992 (31) | 9 | Miami (Fla.) |
| 68 | C. McKivitzColton McKivitz | OT | 6-6 | 301 | 8/9/1996 (27) | 4 | West Virginia |
| 76 | J. MooreJaylon Moore | OT | 6-4 | 311 | 1/9/1998 (25) | 3 | W. Michigan |
| 75 | M. PryorMatt Pryor | OT | 6-7 | 332 | 12/16/1994 (28) | 6 | TCU |
| 71 | T. WilliamsTrent Williams | OT | 6-5 | 320 | 7/19/1988 (35) | 14 | Oklahoma |
| 63 | N. ZakeljNick Zakelj | OT | 6-6 | 316 | 6/22/1999 (24) | 2 | Fordham |
| 65 | A. BanksAaron Banks | OG | 6-5 | 325 | 9/3/1997 (26) | 3 | Notre Dame |
| 74 | S. BurfordSpencer Burford | OG | 6-4 | 300 | 7/19/2000 (23) | 2 | Texas-San Antonio |
Defense
| NO | Player | POS | HT | WT | DOB (AGE) | EXP | College |
|---|---|---|---|---|---|---|---|
| 91 | A. ArmsteadArik Armstead | DE | 6-7 | 290 | 11/15/1993 (29) | 9 | Oregon |
| 97 | N. BosaNick Bosa | DE | 6-4 | 266 | 10/23/1997 (25) | 5 | Ohio State |
| 56 | A. BryantAustin Bryant | DE | 6-5 | 250 | 11/12/1996 (26) | 5 | Clemson |
| 94 | C. FerrellClelin Ferrell | DE | 6-4 | 265 | 5/17/1997 (26) | 5 | Clemson |
| 92 | K. HyderKerry Hyder | DE | 6-2 | 275 | 5/2/1991 (32) | 8 | Texas Tech |
| 95 | D. JacksonDrake Jackson | DE | 6-4 | 273 | 4/12/2001 (22) | 2 | USC |
| 93 | K. DavisKalia Davis | DT | 6-2 | 310 | 10/2/1998 (24) | 2 | UCF |
| 90 | K. GivensKevin Givens | DT | 6-1 | 285 | 3/1/1997 (26) | 4 | Penn State |
| 99 | J. KinlawJavon Kinlaw | DT | 6-5 | 319 | 10/3/1997 (25) | 4 | South Carolina |
| 98 | J. HargraveJavon Hargrave | NT | 6-2 | 305 | 2/7/1993 (30) | 8 | SC State |
| 54 | F. WarnerFred Warner | MLB | 6-3 | 230 | 11/19/1996 (26) | 6 | BYU |
| 48 | O. BurksOren Burks | LB | 6-3 | 233 | 3/21/1995 (28) | 6 | Vanderbilt |
| 45 | D. Flannigan-FowlesDemetrius Flannigan-Fowles | LB | 6-2 | 223 | 9/4/1996 (27) | 4 | Arizona |
| 50 | J. GrahamJalen Graham | LB | 6-3 | 220 | 1/11/2000 (23) | R | Purdue |
| 57 | D. GreenlawDre Greenlaw | LB | 6-0 | 230 | 5/25/1997 (26) | 5 | Arkansas |
| 53 | D. WintersDee Winters | LB | 5-11 | 227 | 10/17/2000 (22) | R | TCU |
| 3 | A. BrownAnthony Brown | CB | 5-11 | 196 | 12/15/1993 (29) | 8 | Purdue |
| 2 | D. LenoirDeommodore Lenoir | CB | 5-10 | 200 | 10/6/1999 (23) | 3 | Oregon |
| 26 | I. OliverIsaiah Oliver | CB | 6-0 | 202 | 9/30/1996 (27) | 6 | Colorado |
| 20 | A. ThomasAmbry Thomas | CB | 6-0 | 190 | 9/9/1999 (24) | 3 | Michigan |
| 7 | C. WardCharvarius Ward | CB | 6-1 | 196 | 5/16/1996 (27) | 6 | Middle Tenn. |
| 30 | G. OdumGeorge Odum | DB | 6-1 | 202 | 11/3/1993 (29) | 6 | Cent. Ark. |
| 27 | J. BrownJi'Ayir Brown | SAF | 5-11 | 202 | 1/25/2000 (23) | R | Penn State |
| 31 | T. GipsonTashaun Gipson | FS | 6-1 | 212 | 8/7/1990 (33) | 12 | Wyoming |
| 29 | T. HufangaTalanoa Hufanga | SS | 6-0 | 200 | 2/1/2000 (23) | 3 | USC |
Special Teams
| NO | Player | POS | HT | WT | DOB (AGE) | EXP | College |
|---|---|---|---|---|---|---|---|
| 4 | J. MoodyJake Moody | K | 6-1 | 210 | 11/23/1999 (23) | R | Michigan |
| 18 | M. WishnowskyMitch Wishnowsky | P | 6-2 | 220 | 3/2/1992 (31) | 5 | Utah |
| 46 | T. PepperTaybor Pepper | LS | 6-4 | 245 | 5/28/1994 (29) | 6 | Michigan St. |