The Dolphins' high-powered offense could face its toughest test yet in Week 13 when Miami visits the San Francisco 49ers. The matchup is one of 13 games on the NFL Week 13 Sunday schedule, which also includes an AFC Championship Game rematch between the Chiefs and Bengals. The Dolphins are second in the NFL in passing yards per game, behind the Chiefs and two spots ahead of the Bengals. That means the quarterbacks in those two games should be popular options. Miami quarterback Tua Tagovailoa is averaging 285 passing yards per game in his nine appearances. He faces a San Francisco defense that allows the fewest yards in the league but is stronger against the run. 

The Dolphins vs. 49ers matchup is set to kick off at 4:05 p.m. ET. Caesars Sportsbook lists the over/under for passing yards on Tagovailoa at 272.5, and he is favored to go over 1.5 TD passes (-145). Can the Niners slow him down, or should you back him for a big week in your Week 13 NFL props? Before locking in your 2022 NFL Week 13 prop bets, make sure you check out the top NFL picks and predictions from NFL props expert Alex Selesnick.

Selesnick (aka PropStarz) specializes in NFL, MLB and NBA prop betting, where he implements a combination of research, statistical analysis and mathematical modeling.

The expert crushed his picks again in Week 12, going 4-0 on predictions that included Over 65.5 Rushing Yards on Miles Sanders of the Eagles. That was despite the running back totaling 25 carries over the previous two games. Sanders got 21 carries against Green Bay on Sunday night and more than doubled his expected rushing total with 143 yards. The perfect week makes PropStarz an astonishing 31-16 on NFL prop picks in this column through the first 12 weeks.

The props guru is 85-52 (+21.20 units) overall on all SportsLine NFL prop picks this season. He also went 130-89 (+26.69 units) on MLB prop plays during the 2022 regular season and is up nearly 235 units on NBA props and futures plays over the past two-plus seasons.

Now, after poring over the hundreds of available Week 13 NFL prop bets, PropStarz has found the picks he loves. You can only see them here

Top 2022 Week 13 NFL prop picks

One player PropStarz is firmly behind is Minnesota receiver Justin Jefferson, and he is backing the superstar to go Over 82.5 receiving yards (-120) against the Jets. New York has one of the league's best secondaries, but the expert says Jefferson is an "auto play anytime we find his receiving line under 90 yards, regardless of opponent." The Vikings have had at least 250 passing yards in seven games this season, including 301 against a tough Patriots defense last week.  

"There is no player I trust more than Jefferson," PropStarz says, and Minnesota quarterback Kirk Cousins would surely say the same. The third-year receiver has 277 career catches for 4,248 yards and 22 touchdowns. He is averaging 112 receiving yards and 10.6 per target this season. He has been targeted at least eight times in eight of the 12 games. New York cornerback Sauce Gardner could make it tough, but PropStars expects Jefferson to prevail. You can see all of PropStarz's Week 13 NFL prop picks here.

How to make 2022 NFL Week 13 prop bets and predictions

PropStarz has locked in three other confident Week 13 NFL prop picks, including a running back who should get plenty of work against a bad defense. He also has a longshot lean on a struggling running back he expects to break out for a payout of almost 20-1. You can only see these picks over at SportsLine.

What are the best 2022 Week 13 NFL prop bets you can make? Which running back could bounce back in a big way and cash a prop that would pay off at almost 20-1? Visit SportsLine now to see the best NFL Week 13 prop bets, all from the expert up more than $2,100 on his SportsLine prop plays this season