Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | J. AllenJosh Allen | M. TrubiskyMitch Trubisky | |
| Running Back | J. CookJames Cook | R. DavisRay Davis | |
| Fullback | R. GilliamReggie Gilliam | — | — |
| Wide Receiver | K. ShakirKhalil Shakir | A. CooperAmari Cooper | |
| Tight End | D. KnoxDawson Knox | D. KincaidDalton Kincaid | |
| Left Tackle | D. EdwardsDavid Edwards | R. Van DemarkRyan Van Demark | |
| Center | C. McGovernConnor McGovern | S. Van Pran-GrangerSedrick Van Pran-Granger | |
| Right Tackle | O. TorrenceO'Cyrus Torrence | T. GrableTylan Grable |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | G. RousseauGreg Rousseau | D. SmootDawuane Smoot | — |
| Right Defensive End | A. EpenesaA.J. Epenesa | V. MillerVon Miller | |
| Left Defensive Tackle | D. JonesDaQuan Jones | J. PhillipsJordan Phillips | |
| Right Defensive Tackle | E. OliverEd Oliver | D. CarterDeWayne Carter | |
| Strongside Linebacker | J. AndreessenJoe Andreessen | B. SpectorBaylon Spector | — |
| Middle Linebacker | T. BernardTerrel Bernard | — | — |
| Weakside Linebacker | M. MilanoMatt Milano | D. WilliamsDorian Williams | |
| Right Cornerback | C. BenfordChristian Benford | K. ElamKaiir Elam | — |
| Left Cornerback | R. DouglasRasul Douglas | C. LewisCam Lewis | — |
| Slot Cornerback | T. JohnsonTaron Johnson | J. IngramJa'Marcus Ingram | |
| Strong Safety | T. RappTaylor Rapp | C. BishopCole Bishop | |
| Free Safety | D. HamlinDamar Hamlin | — | — |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | S. MartinSam Martin | — | — |
| Kicker | T. BassTyler Bass | — | — |
| Long Snapper | R. FergusonReid Ferguson | — | — |
| Holder | S. MartinSam Martin | — | — |
| Punt Returner | K. ShakirKhalil Shakir | B. CodringtonBrandon Codrington | — |
| Kick Returner | K. ShakirKhalil Shakir | T. JohnsonTy Johnson |