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Ole Miss is coming off a thrilling victory over LSU last week but the Rebels will look to avoid a letdown when they host the Arkansas Razorbacks as part of the Week 6 college football schedule on Saturday at 7:30 p.m. ET. The Razorbacks have won six of the last nine meetings against the Rebels, but Arkansas limps into this SEC West showdown having lost three straight games. Ole Miss, meanwhile, is 17-2 in its last 19 games at home.

The Week 6 college football odds via SportsLine consensus list the Rebels as 13-point favorites against the Razorbacks. Other Week 6 college football spreads of note include No. 10 Notre Dame (-6.5) vs. No. 25 Louisville, No. 3 Texas (-5.5) vs. No. 12 Oklahoma in the 2023 Red River Showdown and No. 11 Alabama (-2) vs. Texas A&M in the 3:30 p.m. ET SEC on CBS matchup. Before locking in any Week 6 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of more than $2,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest college football odds for Week 6 and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 6

One of the college football picks the model is recommending for Saturday: Oklahoma (+5.5) stays within the spread against Texas in a noon ET kickoff at the Cotton Bowl in Dallas. No. 12 Oklahoma is 5-0 and is coming off scoring 50 points for the third time this season following a 50-20 win over Iowa State last week. The Sooners are third in college football in scoring (47.4 points per game) led by the left-handed quarterback Dillon Gabriel, who has completed 75.2% of his passes for 1,593 yards and 15 touchdowns compared to two interceptions through five games. He has the seventh-most passing yards in college football.

Gabriel has thrown for at least 320 yards in each of his last three games with nine passing touchdowns and three rushing scores. Oklahoma has defeated Texas straight-up in six of their last eight contests, including four of their last five matchups. Texas has risen to No. 3 in the country in large part to a 34-24 win over Alabama in Week 2 in a 5-0 start, but the model projects Oklahoma to take it down to the wire as the Sooners cover the spread in the Red River Showdown 2023 in more than 60% of simulations.

Another prediction: Georgia (-14.5) easily covers the spread against Kentucky in a 7 p.m. ET kickoff at Sanford Stadium. The Wildcats ran rampant against Florida, recording 329 rushing yards in the 33-14 victory. However, Kentucky has struggled mightily against Georgia over the years, losing 10 straight against the Bulldogs.

Georgia's defense remains one of the best in the nation, giving up just 11.25 points per game this season. Offensively, Georgia is averaging 159 rushing yards and 332.6 passing yards per game. Quarterback Carson Beck is completing 72.1% of his passes for 1,497 yards and seven touchdowns this season. SportsLine's model projects Beck will throw for 270 yards and 2.26 touchdowns on average, helping the Bulldogs cover the spread in nearly 70% of simulations. See which other teams the model likes here.

How to make college football picks for Week 6

The model has also made the call on who wins and covers in every other FBS matchup in Week 6, and it's calling for several underdogs to win outright. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which underdogs win outright? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned more than $2,000 in profit since its inception, and find out.

College football odds for top Week 6 games 

See full Week 6 college football picks, odds, predictions here

Saturday, Oct. 7

Maryland vs. Ohio State (-17, 55.5)

LSU vs. Missouri (+5.5, 64.5)

Oklahoma vs. Texas (-5.5, 60.5)

Washington State vs. UCLA (-3, 59.5)

Virginia Tech vs. Florida State (-24, 52.5)

Syracuse vs. UNC (-9.5, 59)

Colorado vs. Arizona State (+3.5, 59)

Alabama vs. Texas A&M (+2, 45.5)

Kentucky vs. Georgia (-14.5, 46.5)

Notre Dame vs. Louisville (+6.5, 53.5)

Michigan vs. Minnesota (+18.5, 46)

Arkansas vs. Ole Miss (-13, 61)

Georgia Tech vs. Miami (-20, 57)

Fresno State vs. Wyoming (+6, 43)

Oregon State vs. California (+7.5, 50.5)

Arizona vs. USC (-21, 69.5)