College football odds, lines, picks, predictions for Week 2, 2021: Computer model backing Iowa, Michigan

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The Week 2 college football lines from Caesars Sportsbook come in a variety of sizes as non-conference action takes the spotlight on Saturday. No. 9 Iowa State is -4.5 against No. 10 Iowa in one of the top matchups of the day. Other games on the Week 2 college football odds board that are expected to be close include Mississippi State (-1) against NC State and Arizona (-2) against San Diego State. On the other end of the spectrum, Florida is -28.5 against South Florida and Boston College is -37.5 against Massachusetts.

With a limited sample size from this season, there are some tough calls to make for college football bettors. What are the top values in the Week 2 college football spreads? Before making any Week 2 college football picks, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 2 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 2 college football predictions

One of the top college football picks the model is recommending for Week 2: No. 10 Iowa stays within the spread as a 4.5-point underdog against No. 9 Iowa State. There are not many teams in the country that got off to a better start than Iowa. The Hawkeyes were dominant from start-to-finish in their 34-6 win over then-No. 17 Indiana. They picked off Hoosier quarterback Michael Penix Jr. three times and allowed just a pair of field goals.

Running back Tyler Goodson opened the scoring with a 56-yard rushing touchdown to set the tone. Iowa State, meanwhile, is coming off a lackluster Week 1 win over Northern Iowa. Points are always valuable in a rivalry game, which creates some value on Iowa. The model is projecting the Hawkeyes to cover in well over 50 percent of simulations.

Another one of the college football predictions from the model: Michigan (-6.5) covers against Washington at The Big House on Saturday at 8 p.m. ET. Washington opened the season in the AP Top 25, but lost to FCS-level Montana at home in the season opener. Now the Huskies have the unenviable task of traveling to Michigan Stadium to take on a Wolverines squad that is hungry to prove they're contenders in the Big Ten and on a national scale.

Michigan opened its season by blowing out Western Michigan 47-14 and leaned heavily on the running game to get it done. The Wolverines ran it 43 times against just 17 pass attempts and piled up 335 yards on the ground. Meanwhile, Washington gave up 406 yards on the ground in its final two games of the 2020 season.

It's a situation where the line looks fishy given what transpired in Week 1, but the model is adamant that you shouldn't take the bait here. It likes the Wolverines to punch it in a couple times on the ground and for Michigan to cover in well over 60 percent of simulations.

How to make Week 2 college football picks

The model has also made the call on who wins and covers in every other game on the Week 2 college football schedule, and it's calling for multiple outright upsets. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which favorites go down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned $3,500 in profit over the past five-plus seasons, and find out.