A 16-game slate is set in NFL Week 4, and the opening matchup will take place at Lambeau Field. The Detroit Lions will visit the Green Bay Packers in an NFC North clash on Thursday Night Football. Both teams are 2-1 to begin the season and this is the first of two regular season matchups between the rivals. Green Bay erased a 17-point deficit in a monumental win over New Orleans in Week 3, while Detroit cruised to a comfortable, double-digit win over Atlanta.

Kickoff is at 8:15 p.m. ET at Lambeau Field in Green Bay. For this game, the SportsLine Consensus lists Detroit as a two-point favorite, while the over/under, or total number of points Vegas thinks will be scored, is 45 in the latest Packers vs. Lions odds. Before making any Lions vs. Packers picks or NFL predictions, be sure to see what SportsLine's resident Packers expert, R.J. White, has to say, considering his mastery of picks involving Green Bay

White, a Fantasy and gambling editor for CBS Sports, consistently crushes against-the-spread picks and went 535-450-30 on his ATS picks from 2017-22, which returned more than $3,500 to $100 players. He also closed the 2022 NFL season on an incredible 107-80-6 run on his last 193 against-the-spread and total NFL picks, returning more than $1,800 for $100 bettors. Moreover, White has a read on the pulse of the Packers. In fact, he is an incredible 60-21-2 on his last 83 spread picks involving Green Bay. Anyone who has followed him is way up.

Now, White has zeroed in on Packers vs. Lions and just locked in his picks and TNF predictions. You can head to SportsLine to see his picks. Now, here are several NFL odds and betting lines for Lions vs. Packers:

  • Packers vs. Lions spread: Lions -2
  • Packers vs. Lions over/under: 45 points
  • Packers vs. Lions money line: Lions -130, Packers +110
  • DET: Lions are 14-6 against the spread in their last 20 games
  • GB: Packers are 11-9 against the spread in their last 20 games
  • Packers vs. Lions picks: See picks at SportsLine

Why the Lions can cover

Detroit is known best for its robust offense, headlined by the connection between quarterback Jared Goff and receiver Amon-Ra St. Brown. The Lions are also playing well to open the season on defense, including a strong performance in Week 3. Detroit held the Atlanta Falcons to only six points last week, generating seven sacks and allowing fewer than three yards per play. Former No. 2 overall pick Aidan Hutchinson led the way with two sacks, a forced fumble, and a tackle for loss in the game, and that effort helped Detroit to boost its overall 2023 numbers.

The Lions are in the top six of the NFL in yards allowed per play (4.6), and opponents are scoring only 21.0 points per game against Detroit. The Lions are also above-average in total defense, yielding 297.3 yards per game, and Detroit has held opponents to a modest 35.9% third down conversion rate. Detroit is also playing at an elite level against the run, giving up only 72.0 rushing yards per game and 3.2 yards per carry. Green Bay's offense is generating only 90.3 rushing yards per contest, and Detroit is well-equipped to continue that ugly rushing trend. See which team to pick here.

Why the Packers can cover

Jordan Love is in the top five of the NFL in touchdown passes (seven), touchdown percentage (7.0%), and yards per completion (12.8) this season, and he is a true dual-threat option who keeps pressure on opposing defenses with his legs. Love has helped the Packers to top-10 marks in points per game (26.7) and points per drive (2.18), and Green Bay is near the top of the league in third down efficiency (46.5%) and red zone efficiency (77.8%). Ball security has been paramount for Green Bay with only turnover in three games, and Detroit has forced only two turnovers on defense.

The Packers are 14-4 in the last 18 home games, including 1-0 this season at Lambeau Field, and Green Bay has plenty of strengths on defense. The Packers are giving up fewer than five yards per play in 2023, a strongly above-average mark, and Green Bay has given up fewer than 600 passing yards in three games. Green Bay is a top-10 team in third down defense (31.0%) and red zone efficiency allowed (44.4%), and the Packers are facing a Lions team averaging only 3.6 yards per carry this season. See which team to pick here.

How to make Packers vs. Lions picks

White is leaning Under on the point total, and he also has isolated a critical X-factor that has him going big on one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Lions vs. Packers on Thursday Night Football, and which critical X-factor makes one side of the spread hit hard? Visit SportsLine now to see which side of the Lions vs. Packers spread to back, all from the expert who is an astounding 60-21 on spread picks involving Green Bay, and find out.