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The Chicago Cubs and Boston Red Sox clash in a key early-season interleague matchup on Sunday Night Baseball. The Cubs (17-10), who are 7-7 on the road this season, have a plus-15 run differential. The Red Sox (15-13), who are 4-8 at home, have a plus-32 run differential. The teams have split the first two games of the series, with Chicago registering a 7-1 win on Friday and Boston responding with a 17-0 victory on Saturday.

First pitch from Fenway Park is set for 7:10 p.m. ET. Boston is a -137 favorite on the money line (risk $137 to win $100) in the latest Cubs vs. Red Sox odds from SportsLine consensus, while the over/under for total runs scored is 9. Before making any Red Sox vs. Cubs picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 5 of the 2024 MLB season on a profitable 110-85 run on top-rated MLB picks dating back to last season, and it has excelled on top-rated run-line picks during that span, going 19-7 (+737). Anybody following has seen huge returns.

Now, the model has set its sights on Cubs vs. Red Sox and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Red Sox vs. Cubs:

  • Cubs vs. Red Sox money line: Chicago +116, Boston -137
  • Cubs vs. Red Sox over/under: 9 runs
  • Cubs vs. Red Sox run line: Boston -1.5 (+149)
  • CHI: The Cubs are 7-4 in interleague play in 2024
  • BOS: The Red Sox are 3-4 against left-handed pitching this season
  • Cubs vs. Red Sox picks: See picks at SportsLine

Why you should back the Red Sox

Right fielder Tyler O'Neill is on a six-game hitting streak. In Saturday's win over the Cubs, he was 3-for-5 with a double, home run, two RBI and three runs scored. He had two hits with a homer in Friday's loss. O'Neill, who spent the first six years of his career with the St. Louis Cardinals, is familiar with Chicago. In 50 career games against the Cubs, he is batting .275 with five doubles, one triple, 10 homers and 25 RBI.

Third baseman Rafael Devers has hits in his last four games, including a 3-for-5 effort in a 6-4 loss at Cleveland on Thursday. He was 3-for-4 with a double, home run and two RBI in an 8-0 win at Cleveland on Wednesday. In 17 games this season, he is batting .262 with four doubles, three homers and seven RBI. See which team to pick here

Why you should back the Cubs

Among Chicago's top hitters is second baseman Nico Hoerner. In 26 games, he is batting .283 with seven doubles, one triple, seven RBI and 17 runs scored. He had a three-game hitting streak snapped on Saturday, but has hits in seven of his past nine games. He also has five multiple-hit games over that span, including a 3-for-5 performance with two doubles and two RBI in a 6-3 loss to Miami on April 21.

Cody Bellinger has also been effective at the plate for Chicago. He leads the team with 17 RBI to go along with 19 hits, 10 runs scored and five home runs. First baseman Michael Busch boasts a .287 batting average and leads the team with six homers. Through the first two games of this series, Busch has racked up four hits, two runs scored and one RBI. See which team to pick here

How to make Red Sox vs. Cubs picks

SportsLine's model is leaning Over on the total, projecting 10.3 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Cubs vs. Red Sox on Sunday Night Baseball, and which side of the money line should you back? Visit SportsLine now to see which side you need to jump on, all from the model that's 110-85 on top-rated MLB picks, and find out.