Kentucky will try to snap out of its losing funk when it faces No. 25 Louisville on Saturday afternoon during rivalry week in college football. The Wildcats have lost three of their last four games, including a 16-6 setback against No. 1 Georgia last week. They are still 3-point favorites in the Governor's Cup, though, according to the latest Week 13 college football odds at Caesars Sportsbook. Louisville has won five of its last six games, so should you be backing the Cardinals with your Week 13 college football bets?

There are a trio of ranked vs. ranked matchups on Saturday as well, including No. 2 Ohio State (-8) vs. No. 3 Michigan in The Game. Elsewhere, No. 21 Oregon State (+3) is playing host to No. 9 Oregon, and No. 6 USC (-5) is facing No. 15 Notre Dame. Before making any Week 13 college football picks, be sure to see the latest college football predictions from SportsLine's advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has turned its attention to the latest Week 13 college football odds from Caesars and locked in picks for every FBS matchup. Head here to see every pick.

Top college football predictions for Week 13

One of the college picks the model is high on in Week 13: Army (-20) covers at UMass in a noon ET kickoff on Saturday. The Minutemen have been a struggling program for years, and nothing has changed this season. They have lost eight straight games, including a 20-3 setback at Texas A&M last week. UMass is also coming off three consecutive road games, making this a tough scheduling spot.

Army snapped its two-game skid with a 34-17 win over UConn last week, easily covering the 10.5-point spread. The Black Knights racked up 318 rushing yards and four touchdowns, averaging 5.5 yards per carry. They have covered the spread in four of their last five games, while UMass has only covered seven times in its last 20 contests. 

Another one of the Week 13 college football picks from the model: Tennessee (-14) covers on the road against Vanderbilt in a 7:30 p.m. ET kickoff on Saturday night. A devastating loss to South Carolina last week ended Tennessee's realistic College Football Playoff chances and the loss of Hendon Hooker (ACL) only makes things tougher. However, Tennessee is better-prepared than most for such an occurrence.

Backup quarterback Joe Milton III was a starter at Michigan and then won the job at Tennessee outright last season before Hooker overtook him. But he decided to stick around and his skillset is pretty well-suited for an offense that wants to challenge defenses vertically. He has an absolute cannon and has averaged a staggering 17.4 yards per pass while throwing six touchdowns in 33 attempts as a reliever. The model has Milton leading an offense that puts up 41 points with Tennessee covering in well over 60% of simulations and winning by an average margin of 24 points. See which other teams the model likes here.

How to make college football picks for Week 13

The model has also made the call on who wins and covers in every other FBS matchup in Week 13, and it says several top-25 teams will go down hard. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence? And which top-25 teams go down hard? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned almost $3,000 in profit over the past six-plus seasons, and find out.

College football odds for Week 13 (via Caesars)

See full Week 13 college football picks, odds, predictions here

Saturday, Nov. 26

South Carolina at Clemson (-14.5, 50.5)

Featured Game | Clemson Tigers vs. South Carolina Gamecocks

Georgia Tech at Georgia (-35.5, 48.5)

Michigan at Ohio State (-8, 57)

Featured Game | Ohio State Buckeyes vs. Michigan Wolverines

Oregon at Oregon State (+3.5, 56.5)

Featured Game | Oregon State Beavers vs. Oregon Ducks

Auburn at Alabama (-21.5, 48.5)

Featured Game | Alabama Crimson Tide vs. Auburn Tigers

Iowa State at TCU (-10, 47.5)

Featured Game | TCU Horned Frogs vs. Iowa State Cyclones

LSU at Texas A&M (+9.5, 46.5)

Featured Game | Texas A&M Aggies vs. LSU Tigers

Notre Dame at USC (-5, 62.5)

Featured Game | USC Trojans vs. Notre Dame Fighting Irish

Washington at Washington State (+2, 58.5)

Featured Game | Washington State Cougars vs. Washington Huskies