The San Diego Padres will attempt to salvage a split of their four-game series with the Chicago Cubs on Monday night. First pitch is scheduled for 9:10 p.m. ET from Petco Park in San Diego. The middling Padres (27-32) have split their last 10 games and are just 13-17 at home this season. They enter Monday 7.5 games behind the Arizona Diamondbacks in the NL West race following a 7-1 defeat to Chicago on Sunday. The Cubs (26-32) have won four of their last six following a four-game losing streak. Chicago will turn to Kyle Hendricks (0-1, 3.86 ERA), who will make his third start as he continues to make his way back from a shoulder injury. He is 8-2 with a 2.61 ERA in 13 career starts against San Diego. The Padres will counter with Blake Snell (1-6, 4.50), who allowed a season-high six runs in his previous home outing against Boston. 

The Padres are -175 betting favorites (risk $175 to win $100), while the Cubs are offered at +150 in the latest MLB odds from Caesars Sportsbook. The over/under for total runs scored is 8.5. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven simulation model

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons. It has opened the 2023 MLB season on a 32-24 roll on all-top rated MLB picks (+142). Anybody who has followed it has seen profitable returns.

For Monday, the model has locked in three confident MLB best bets for games that begin at 7:10 p.m. ET or later. If you successfully parlay the picks, you'd be looking at a payout of nearly 8-1. You can only see the model's MLB picks at SportsLine.

Top MLB picks today

After simulating every game on Monday 10,000 times, the model is picking the Milwaukee Brewers (+110) to pull the mild upset of the Cincinnati Reds (-130). The model sees Milwaukee winning this matchup at least half the time, providing a major value at the plus-money odds. First pitch is set for 7:10 p.m. ET from Great American Ball Park. The first-place Brewers have dominated this NL Central rivalry of late, going 21-7 in the past 28 meetings. They also enter Monday on a 4-1 run on their past five road games. Conversely, the Reds have dropped four straight and are in danger of absorbing a four-game sweep with another loss Monday.

The Brewers are set to send out right-hander Julio Teheran (1-1, 0.82), who will make his third start of the season following an impressive performance. He allowed one earned run over six innings to pick up a victory in a 4-2 win over the Blue Jays last Wednesday. The Reds will counter with Left-hander Andrew Abbott (0-0, 0.00 ERA), who will be making his major-league debut due to injuries to several members of the Cincinnati staff. He will become the fifth Reds pitcher to make his MLB debut this season. See who else to back here.

How to make MLB parlays for Monday, June 5 

The model also locked in two other best bets for Monday, including a play on an underdog that would return plus-money. You can only see the model's MLB parlay picks and best bets at SportsLine

What MLB picks should you target for a payout of nearly 8-1, and what underdog does the model like on Monday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 32-24 run on top-rated money-line picks, and find out.