The Florida State Seminoles will look to continue their home dominance when opening a new season on Saturday as they take on the Duquesne Dukes. The Seminoles (5-7 in 2021) are 30-11 (.732) when opening a season at home, including an 18-5 (.783) record since 1975. FSU has had a lot of success overall in season openers as well, going 54-21 (.720). Duquesne is 2-8 all-time against current Atlantic Coast Conference members, with its last meeting being a 53-20 loss to Clemson in 1950.

Kickoff from Doak Campbell Stadium in Tallahassee, Fla., is set for 5 p.m. ET. Duquesne allowed 22.9 points per game in 2021, while Florida State gave up 26.5. The Seminoles are favored by 41.5 points in the latest Florida State vs. Duquesne odds from Caesars Sportsbook, while the over/under for total points scored is 57. Before making any Duquesne vs. Florida State picks, make sure you check out the college football expert picks from SportsLine's Emory Hunt.

Hunt is the founder and CEO of Football Gameplan, which has been supplying analysis of all levels of football since 2007, and a former running back at Louisiana-Lafayette. He knows the game from a player's perspective. Hunt has gone an amazing 14-5 on his last 19 picks involving Florida State, returning $850. Anyone who has followed him is way up.

Now, Hunt has set his sights on FSU vs. Duquesne and just locked in his picks and CFB predictions. You can head to SportsLine now to see his picks. Now, here are several college football odds and betting lines for Duquesne vs. FSU:

  • Florida State vs. Duquesne spread: Florida State -41.5
  • Florida State vs. Duquesne over/under: 57
  • DUQ: Last season the Dukes ranked second in the NEC in scoring, averaging 29.5 points per game.
  • FSU: The Seminoles have 84 underclassmen on their roster with only 12 seniors.
  • Florida State vs. Duquesne picks: See picks at SportsLine 

Why Florida State can cover

The Seminoles return a key piece to their defense in redshirt junior free safety Jammie Robinson. Robinson was impressive last season, leading the team in tackles with 84, including 42 solo. He also knocked down three passes and picked off four others. He also forced two fumbles. In last year's season finale at Florida, Robinson registered 18 tackles, including six solo. For his career, which began at South Carolina, he has 220 tackles, including 135 solo, with 11 pass breakups, three forced fumbles and six interceptions.

The offense will once again be led by redshirt junior quarterback Jordan Travis. He has played in 22 games at FSU and is 200-for-336 passing for 2,674 yards and 21 touchdowns, while rushing for 1,317 yards and 17 touchdowns on 254 carries. Travis ranked fifth in the ACC in completion percentage at 62.9, and topped 62.1 percent passing in six of his 10 games. He also posted better than 80 percent completion percentage twice.

Why Duquesne can cover

The Dukes sport a solid one-two punch in the offensive backfield. Duquesne returns second-team All-NEC selection Billy Lucas, and welcomes Samford graduate transfer DeMarcus Ware at running back. Lucas led the team with 699 yards rushing on 137 carries (5.1 average) with six touchdowns. He posted over 100 yards rushing twice, including a season high with 137 yards at Long Island to earn NEC Offensive Player of the Week honors.

Ware joins the Dukes after rushing for 976 yards over parts of the past four seasons. Last year, Ware appeared in nine games and rushed 73 times for 279 yards and seven touchdowns. In his most productive game, he carried the ball 26 times for 118 yards and three touchdowns at Western Carolina. He was named to the 2018 SoCon All-Freshman Team, but ran into injuries in his sophomore and junior seasons.

How to make Duquesne vs. FSU picks

For Saturday's contest, Hunt is leaning Over on the total, and he's also isolated a critical X-factor he believes makes one side of the spread a must-back. He's sharing what it is, and which side of the spread he's backing, only at SportsLine.

So who wins Florida State vs. Duquesne? And which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to find out which side of the spread you need to jump on Saturday, all from the expert who has crushed his college football picks, and find out.