No. 19 Colorado will try to spring its second big upset of the season when it travels to No. 10 Oregon in a Pac-12 opener on Saturday afternoon. The Buffaloes knocked off then-No. 17 TCU as 21-point underdogs in their season opener, and they have added wins over Nebraska and Colorado State since then. Oregon has notched blowout victories over Portland State and Hawaii while taking down Texas Tech on the road. Colorado coach Deion Sanders is in his first season with the team; Oregon coach Dan Lanning is in his second season with the Ducks.

Follow live updates and highlights from Colorado vs. Oregon.

Kickoff is set for 3:30 p.m. ET at Autzen Stadium in Eugene. The latest Colorado vs. Oregon odds via the SportsLine consensus list the Ducks as 21-point favorites, with the over/under at 70.5, which is down two points from the opener. Before locking in any Colorado vs. Oregon picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed the model has seen huge returns.

Now, the model has set its sights on Oregon vs. Colorado and just revealed its picks and predictions. You can visit SportsLine now to see the model's CFB picks. Here are several college football odds and trends for Colorado vs. Oregon:

  • Colorado vs. Oregon spread: Ducks -21
  • Colorado vs. Oregon over/under: 70.5 points
  • Colorado vs. Oregon money line: Ducks -906, Buffaloes +592
  • ORE: The Ducks rank second in the country in scoring offense (58.0 points per game)
  • COL: Shedeur Sanders is second in the nation in total offense (397.3 yards per game)
  • Colorado vs. Oregon: See picks at SportsLine 
  • Colorado vs. Oregon live stream: fubo (try for free)

Why Oregon can cover

The Ducks figure to have a terrific matchup with their passing offense going up against the Colorado pass defense. Led by quarterback Bo Nix, Oregon ranks fifth in the country in passing yards per game (363.3). That bodes well against a Buffaloes pass defense that allows 265.0 passing yards per game, which ranks 107th in the nation.

That Colorado pass defense will be further limited with the loss of two-way star Travis Hunter, who will miss the game with a lacerated liver. Ranked by 247Sports as the top player in the 2022 recruiting class, this cornerback/receiver has played the most snaps in the FBS this season, with 339 (149 on offense, 180 on defense and 10 on special teams). In the season-opening upset of No. 17 TCU, Hunter made a diving interception in the red zone to thwart a Horned Frogs scoring threat. See which team to pick here.

Why Colorado can cover

Colorado has already proven it can win a game as a massive underdog, and the Buffaloes have covered the spread in two of their first three games this season. They have scored more than 35 points in all three contests, which will make it difficult for Oregon to cover the huge number. Junior quarterback Shedeur Sanders has thrown for 1,251 yards, 10 touchdowns and just one interception while rushing for an additional score.

Freshman running back Dylan Edwards has added 136 rushing yards, averaging 5.4 yards per carry. Oregon has only faced one legitimate opponent this season, and it trailed Texas Tech by nine points heading to the fourth quarter of that game. The Ducks failed to cover the spread in three of their final four games last season, so they are potentially overvalued based on their three ATS victories to open this season. See which team to pick here.

How to make Oregon vs. Colorado picks

SportsLine's model is leaning Under on the point total, projecting the teams to combine for 65 points. The model also says one side of the spread hits in more than 60% of simulations. You can see the model's picks at SportsLine

So who wins Colorado vs. Oregon, and which side of the spread hits more than 60% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has notched a profit of almost $2,500 on its top-rated college football spread picks, and find out.