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The No. 4 North Carolina Tar Heels (13-3) will try to extend their six-game winning streak when they host the Louisville Cardinals on Wednesday night. UNC cruised to a 103-67 win against Syracuse on Saturday, easily covering the 12-point spread. Louisville has lost four of its last five games, including an 89-83 setback against NC State on Saturday. The Tar Heels are the only team unbeaten in ACC play, while the Cardinals are sitting ahead of Pittsburgh at the bottom of the league standings. 

Tipoff is set for 9 p.m. ET on Wednesday at the Dean E. Smith Center. The Tar Heels are favored by 21 points in the latest North Carolina vs. Louisville odds, while the over/under is 155.5 points. Before entering any Louisville vs. North Carolina picks, you'll want to see the NCAA Basketball predictions from the model at SportsLine.

The model simulates every Division I college basketball game 10,000 times. It enters Week 11 of the 2023-24 season on a 110-73 roll on all top-rated college basketball picks dating back to last season, returning more than $2,000 for $100 players. It is also off to a sizzling 15-5 start on top-rated spread picks this season. Anyone following has seen huge returns.

The model has set its sights on Louisville vs. UNC. You can head to SportsLine to see its picks. Here are several college basketball betting lines for the game:

  • North Carolina vs. Louisville spread: UNC -21
  • North Carolina vs. Louisville over/under: 155.5 points
  • North Carolina vs. Louisville money line: UNC -2434, Louisville +1163
  • North Carolina vs. Louisville picks: See picks here

Why North Carolina can cover

North Carolina has been on fire since the end of December, rattling off a six-game winning streak that started with a double-digit win at then-No. 7 Oklahoma. The Tar Heels have added a trio of conference road wins, including a 65-55 win at then-No. 16 Clemson earlier this month. Their latest victory was a 103-67 blowout over Syracuse on Saturday, taking a 22-point lead at halftime before piling it on even more in the second half. 

Senior forward Armando Bacot (16 points, 11 rebounds) and junior forward Harrison Ingram (11 points, 10 rebounds) each posted double-doubles in the win, while senior guard RJ Davis scored a game-high 22 points. Davis has reached the 20-point mark in 10 games, and North Carolina had a season-high 13 steals against Syracuse. The Tar Heels are 7-0 at home this season, and their 5-0 start in ACC play is their best since the 2015-16 campaign. 

Why Louisville can cover

Louisville has shown some encouraging signs over the past week after a rough stretch from the beginning of December to the beginning of January. The Cardinals went on the road and pulled off a massive upset at Miami, beating the Hurricanes by 16.5-point underdogs last Wednesday. Sophomore guard Mike James scored 26 points on 8 of 12 shooting, knocking down 5 of 6 attempts from 3-point range. 

Junior forward Brandon Huntley-Hatfield added 22 points, nine rebounds and two assists, shooting 9 of 13 from the floor. The Cardinals proceeded to cover the spread as 7-point underdogs in a narrow loss to NC State on Saturday, as four Louisville players scored at least 13 points. Huntley-Hatfield posted his fourth double-double in his last seven games, finishing with 13 points and 10 rebounds. See which team to pick here. 

How to make UNC vs. Louisville picks

The model has simulated Louisville vs. North Carolina 10,000 times and the results are in. The model is leaning Under, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You can only see the pick at SportsLine.

So who wins Louisville vs. UNC, and which side of the spread hits almost 60% of the time? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that is on a 110-73 roll on its top-ranked college basketball picks, and find out.