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The No. 17 Duke Blue Devils (6-2) host the No. 25 Ohio State Buckeyes (5-1) on Wednesday in a 2022 ACC-Big Ten Challenge matchup. The Blue Devils look to get back on track after suffering a commanding loss on Sunday, when Duke fell to No. 5 Purdue 75-56 in the Phil Knight Legacy Championship Game. Meanwhile, Ohio State is on a two-game win streak. The Buckeyes have a 3-3 record against the spread while Duke is 4-4 against the number.

Tip-off from the Cameron Indoor Stadium in Durham, N.C. is set for 7:15 p.m. ET. The Blue Devils are 5.5-point favorites in the latest Ohio State vs. Duke odds from Caesars Sportsbook, while the over/under for total points scored is 135. Before locking in any Duke vs. Ohio State picks, be sure to see the college basketball predictions and betting advice from SportsLine's proven computer model

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six years, the proprietary computer model has generated an impressive profit of more than $1,200 for $100 players on its top-rated college basketball picks against the spread. 

Now, the model has set its sights on Ohio State vs. Duke, and just locked in its picks and CBB predictions. You can visit SportsLine now to see the model's picks. Here are the college basketball odds and betting lines for Duke vs. Ohio State:

  • Ohio State vs. Duke spread: Blue Devils -5.5 
  • Ohio State vs. Duke Over/Under: 135 points  
  • Ohio State vs. Duke Moneyline: Blue Devils -230, Buckeyes +190 
  • OSU: Over is 5-2 in Buckeyes' last 7 Wednesday games 
  • DUKE: Blue Devils are 4-1 ATS in their last 5 Wednesday games 
  • Ohio State vs. Duke picks: See picks here
Featured Game | Duke Blue Devils vs. Ohio State Buckeyes

Why Duke can cover

Freshman forward Kyle Filipowski is a versatile and multi-talented force in the frontcourt. Even though Filipowski is 7 feet, he is able to handle the rock and create his own shot. The New York native can space the floor and be a shooting threat from the perimeter. Filipowski leads the team in both points (15.4) and rebounds (9.4). On Nov. 24, he scored 19 points and grabbed 14 rebounds. 

Junior Jeremy Roach is the lead guard on the floor. Roach plays with his head up and knows how to penetrate the lane. He excels in transition and finding the open man. The Virginia native owns a great feel for operating the offense and scores well in the midrange. Roach averages 12.9 points, 2.5 rebounds, and 3.6 assists per game. On Nov. 25, he logged 21 points, four rebounds, five assists, and two steals.

Why Ohio State can cover

Junior Zed Key is a strong and physical forward who can score from the low post and barrel his way right to the basket. Additionally, Key knows how to position himself to snag boards while defending the opposing team's best player at times. The New York native averages 12.5 points and 8.5 rebounds per game. On Nov. 22, he dropped 19 points and eight rebounds.

Freshman guard Bruce Thornton is terrific with the ball in his hands and has a sound jumper. Thornton can be a menace defensively due to his active hands and excellent effort. The Georgia native also has great lateral quickness and can force his opponent into difficult shots. Thornton logs 9.2 points, 2.7 rebounds, and 2.7 assists per game. He's finished in double figures in two of his last three games. 

How to make Ohio State vs. Duke picks

SportsLine's model is leaning Over on the point total, projecting the teams to combine for 144 points. The model also says one side of the spread has all of the value. You can only get the model's CBB picks at SportsLine

So who wins Ohio State vs. Duke? And which side of the spread has all of the value? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.