The South Carolina Gamecocks can move one step closer to making history when they square off against the Iowa Hawkeyes in the 2023 Women's Final Four on Friday at American Airlines Center in Dallas. South Carolina (36-0) is looking to become just the fifth program in history to have an undefeated, national championship-winning season. The feat was previously accomplished by Texas, UConn (six times), Tennessee and Baylor. To join that club, the Gamecocks will have to knock off the red-hot Hawkeyes (30-6). 

The teams will tip off after the first semifinal between Virginia Tech and LSU, at approximately 9 p.m. ET. The Gamecocks are 11-point favorites in the latest South Carolina vs. Iowa odds from Caesars Sportsbook, while the over/under is 151.5. Before locking in any Iowa vs. South Carolina picks or Women's Final Four predictions, you need to see what SportsLine women's basketball experts Calvin Wetzel and Aaron Barzilai have to say.

Barzilai is a Ph.D. from Stanford who served as Director of Basketball Analytics for the Philadelphia 76ers. Five years ago, he founded HerHoopStats.com -- a groundbreaking website that unlocks insights about the women's game. Wetzel, the site's lead betting writer, incorporates his mathematical background and strong knowledge of women's hoops to turn the site's prediction model into picks.

Barzilai and Wetzel went 590-430 overall (+127.40 units) during the 2021-22 women's college basketball campaign and posted a 406-255-5 record (+768.81 units) this past season. They also finished the WNBA regular season with a 54-44 mark in 2022. Anyone who has followed them has seen huge returns.

Now, Wetzel and Barzilai have set their sights on South Carolina vs. Iowa in the Women's Final Four and just locked in their picks and best bets. You can head to SportsLine now see the picks. Here are the college basketball lines and trends for Iowa vs. South Carolina:

  • South Carolina vs. Iowa spread: Gamecocks -11 
  • South Carolina vs. Iowa over/under: 151.5 points 
  • South Carolina vs. Iowa money line: Gamecocks -475, Hawkeyes +360
  • SC: The Gamecocks lead the country in scoring margin (29.5 points per game)
  • IOWA: Caitlin Clark leads the nation in triple doubles (five) 
  • South Carolina vs. Iowa picks: See picks at SportsLine

Why the Gamecocks can cover

South Carolina has been dominant the entire season. The Gamecocks' average margin of victory this season is 29.5 points per game, which leads the country. In four NCAA Tournament games, South Carolina is winning by 22.5 points a game and hasn't won by fewer than 11 points.

In addition, the Gamecocks have an explosive guard in Zia Cooke. A 5-foot-9 senior from Toledo, Ohio, Cooke leads the team in scoring (15.1 points per game) while shooting 78.9% from the free throw line. For her efforts this season she earned third team AP all-America honors.

Why the Hawkeyes can cover

Iowa has a next-level superstar in Caitlin Clark. A do-it-all 6-foot guard with seemingly unlimited shooting range, Clark is the first Div. I women's basketball player to have more than 900 points (984) and 300 assists (311) in a single season. She averages 27.3 points, 7.3 rebounds and 8.6 assists per game and already has been named the AP and Naismith Women's Player of the Year.

Clark is the engine to an offense that's the best in the country. The Hawkeyes lead the nation in points per game (87.6), assists per game (21.1) and field goal percentage (51.1). During the NCAA Tournament, they have been even better, averaging 88.2 points per game.

How to make South Carolina vs. Iowa picks

Wetzel and Barzilai have analyzed this matchup and locked in their best bet. They've found a critical x-factor they believe makes this pick hit hard. They're only sharing what it is and which side to back at SportsLine.

What is the best bet for South Carolina vs. Iowa in the Women's Final Four? What critical X-factor makes it hit hard? Visit SportsLine now to see what Iowa vs. South Carolina pick you should jump on -- all from the experts who are an outstanding 406-255-5 on their women's college basketball picks this season, and find out.