ACC college basketball foes clash on Saturday afternoon when the Notre Dame Fighting Irish (6-1) host the Syracuse Orange (3-4). Syracuse is leading the all-time series 33-21 over Notre Dame. In 2021, Notre Dame knocked off the Orange 79-69. Both teams have struggled against the spread thus far with Notre Dame at 1-5 ATS and Syracuse at 2-5 ATS.

Tip-off from the Purcell Pavilion in South Bend is set for noon ET. The Fighting Irish are 6.5-point favorites in the latest Syracuse vs. Notre Dame odds from Caesars Sportsbook, while the over/under for total points scored is 136. Before locking in any Notre Dame vs. Syracuse picks, be sure to see the college basketball predictions and betting advice from SportsLine's proven computer model

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six years, the proprietary computer model has generated an impressive profit of more than $1,500 for $100 players on its top-rated college basketball picks against the spread. 

Now, the model has set its sights on Notre Dame vs. Syracuse, and just locked in its picks and CBB predictions. You can visit SportsLine now to see the model's picks. Here are the college basketball odds and betting lines for Syracuse vs. Notre Dame:

  • Syracuse vs. Notre Dame spread: Fighting Irish -6.5
  • Syracuse vs. Notre Dame over/under: 136 points
  • Syracuse vs. Notre Dame money line: Fighting Irish -300, Orange +240
  • SYR: Under is 4-0 in Orange last four games following an ATS loss
  • ND: Fighting Irish are 22-8-1 ATS in their last 31 Saturday games
  • Syracuse vs. Notre Dame picks: See picks at SportsLine
Featured Game | Notre Dame Fighting Irish vs. Syracuse Orange

Why Notre Dame can cover

Senior guard Dane Goodwin is an athletic and impactful scorer for the Fighting Irish. Goodwin can constantly score off the dribble with a reliable jumper from downtown. The Ohio native can also finish with either hand at the rim. Goodwin averages 14 points, 4.7 rebounds while shooting 48% from downtown. He's dropped at least 12 points with two 3-pointers in three of his last five games.

Senior Cormac Ryan is a smart and skilled combo guard who can really shoot the basketball. Ryan excels in his role offensively and thrives in catch-and-shoot situations. The New York native moves well without the ball and is a confident shooter. Ryan logs 11.9 points, 4.3 rebounds and is knocking down 37% of his attempts from 3-point land.

Why Syracuse can cover

Freshman guard Judah Mintz is a natural scorer and calm facilitator for the Orange offense. Mintz has explosive quickness and great ball handles to get past his defender. The Maryland native is putting up a team-high 15.1 points with 3.1 assists per game. On Nov. 22, Mintz amassed 20 points, two boards and two dimes.

Senior center Jesse Edwards is a big-bodied presence (6-foot-11, 230 pounds) who uses his size to his advantage. Edwards has a soft touch around the rim with great hands to snag boards consistently. The Netherlands native is leading the team in rebounds (11.3) and blocks (2.7) with 13.7 points per game. On Nov. 29, he supplied nine points, 17 rebounds and three blocks. 

How to make Syracuse vs. Notre Dame picks

SportsLine's model is leaning Over on the point total, projecting the teams to combine for 147 points. The model also says one side of the spread hits more than 50% of the time. You can only get the model's CBB picks at SportsLine

So who wins Notre Dame vs. Syracuse? And which side of the spread hits more than 50% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.