2022 March Madness predictions: College basketball expert picks, odds, lines for Elite Eight games Saturday

A closer look at the Elite Eight games on Saturday's slate for the NCAA Tournament

By Kyle Boone

Mar 26, 2022 at 7:34 pm ET • 2 min read

USATSI

After we saw the early exit of three of the four No. 1 seeds during the Sweet 16, multiple double-digit seeds dancing into the Elite Eight and frequent upsets, your bracket is probably busted leaving it a shambles. The 2022 NCAA Tournament has been wild, but that March Madness drama has a chance to continue Saturday as the Elite Eight gets underway, kicking off the first of a two-day forum that will almost certainly invite more chaos ahead of next week's Final Four.

Kicking off the weekend is perhaps the best matchup of the Elite Eight as No. 2 seed Villanova and No. 5 seed Houston square off for rights to claim the South Regional. The lower-seeded Cougars are the favorite (by a smidge) in the eyes of oddsmakers fresh off a convincing win over No. 1 seed Arizona on Thursday, but they draw a Wildcats team that is winning by an average margin of nearly 13 points in the tournament.

The finale of Saturday features another giant killer in No. 4 seed Arkansas, which sent No. 1 overall seed Gonzaga home in the Sweet 16 after leading for nearly the entire second half in one of the most impressive outings of any team in this year's tournament. The Razorbacks draw No. 2 seed Duke and retiring coach Mike Krzyzewski with a Final Four berth on the line. After surviving a scare against No. 3 seed Texas Tech, the Blue Devils are a slight favorite to advance into the next round.

Be sure to stick with CBS Sports throughout the rest of the month for NCAA Tournament coverage through the end of the Final Four. Let's take a look at our expert picks for the Elite Eight games on Saturday.

Odds via Caesars Sportsbook | All times Eastern

NCAA Tournament: Elite Eight picks for Saturday

(2) Duke vs. (4) Arkansas

Saturday, 8:49 p.m. | TBS, March Madness Live: Arkansas handled No. 1 overall seed Gonzaga in the Sweet 16, outclassed the Zags with its physicality and athleticism. And while that almost certainly won't be the case against Duke, which has multiple first-round NBA Draft prospects on the roster, I do think coach Eric Musselman and his team can cover here even against a Blue Devils team that appears to be hitting its stride just in time. Pick: Arkansas +3.5

	Parrish	Norlander	Palm	Boone	Cobb	Patterson
Spread	ARK +3.5	DUKE -3.5	ARK +3.5	ARK +3.5	DUKE -3.5	ARK +3.5
Straight up	DUKE	DUKE	ARK	DUKE	DUKE	DUKE

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(2) Villanova vs. (5) Houston

Saturday, 6:09 p.m. | TBS, March Madness Live: As of Friday morning, Houston owns the second-best odds of winning the NCAA championship after dispatching -- quite handily, I should add -- No. 12 seed UAB, No. 4 seed Illinois and No. 1 seed Arizona to open the tournament. But Villanova's run has quietly been just as impressive with three convincing wins topped by a Sweet 16 victory over a Michigan team that had the personnel to give the Wildcats fits but couldn't capitalize. I trust their experience and ability to play and win different ways, so in a close one, I'll just take the points with Nova. Pick: Villanova +2