Red Sox vs. Orioles odds, line, score prediction, start time: 2024 MLB picks, May 27 best bets by proven model

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The Baltimore Orioles will look to extend their winning streak over the Boston Red Sox to four games when they meet on Monday afternoon in Baltimore. Baltimore won all three games at Fenway Park in Boston in April, and has won four of its last five meetings against its division rival. The Orioles (33-18), who trail the first-place New York Yankees by two games in the American League East standings, are 17-10 at home this year. The Red Sox (27-26), who have lost five of their last seven series, are 16-11 on the road in 2024.

The game is slated to begin at 1:05 p.m. ET from Oriole Park at Camden Yards. The Red Sox are batting .243 as a team this season, 12th-best in MLB, while the Orioles are hitting .242, 15th-best. The Orioles are -159 favorites (risk $159 to win $100) on the money line in the latest Red Sox vs. Orioles odds from SportsLine consensus, while the over/under for total runs scored is 9. Before making any Orioles vs. Red Sox picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 8 of the 2024 MLB season on a profitable 123-99 run on top-rated MLB picks dating back to last season, and it has excelled on top-rated run-line picks during that span, going 20-8 (+708). Anybody following has seen huge returns.

Now, the model has set its sights on Red Sox vs. Orioles and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Orioles vs. Red Sox:

Red Sox vs. Orioles money line: Baltimore -159, Boston +135
Red Sox vs. Orioles over/under: 9 runs
Red Sox vs. Orioles run line: Baltimore -1.5 (+125)
BOS: The Red Sox are 6-9 against left-handed pitching in 2024
BAL: The Orioles are 17-9 in day games this season
Red Sox vs. Orioles picks: See picks at SportsLine

Why you should back the Orioles

Baltimore is expected to send left-hander Cole Irvin (4-2, 3.15 ERA) to the mound and he'll be backed by a lineup that ranks second in the majors in slugging percentage. Third baseman Jordan Westburg has been heating up of late. In Saturday's 5-3 victory over the Chicago White Sox, he was 3-for-4 with a homer. In 49 games this season, he is hitting .284 with 10 doubles, three triples, eight homers, 31 RBI and 27 runs scored. In eight career games against Boston, he is batting .350 with three doubles, two homers and four RBI.

Another offensive weapon for the Orioles is first baseman Ryan Mountcastle. The former first-round draft pick from 2015 is on a five-game hitting streak. In Thursday's 8-6 win over the White Sox, Mountcastle was 4-for-5 with a double. He was 1-for-4 with a double in Sunday's 4-1 win. In 46 games this season, he is batting .271 with 14 doubles, one triple, six homers, 19 RBI and 26 runs scored. See which team to pick here.

Why you should back the Red Sox

Right-hander Cooper Criswell (2-1, 2.86 ERA) will start for Boston. In eight games, including seven starts, Criswell has walked eight batters, while striking out 34 in 34.2 innings. He will be looking for his first decision since defeating San Francisco 4-0 on April 30. In that game, he pitched five innings, allowing two hits and one walk, while striking out four. In his last outing, a 5-2 win at Tampa Bay, he received a no-decision despite pitching 5.1 innings, allowing six hits, two earned runs and one walk, while striking out six.

Third baseman Rafael Devers continues to be one of Boston's top hitters. In Saturday's 6-3 loss to the Milwaukee Brewers, he was 2-for-4 with a double and two runs scored. He has hits in seven of his past 10 games, including two multi-hit games. He was 2-for-4 with a homer and two runs scored in a 7-5 loss to Tampa Bay on May 16. In 42 games this season, he is hitting .272 with 11 doubles, 10 homers, 24 RBI and 27 runs scored. See which team to pick here.