The Arizona Diamondbacks face the St. Louis Cardinals in the third and final game of their series on Wednesday. Arizona knotted the series at 1-1 with a 14-1 thrashing of St. Louis on Tuesday, after losing 5-3 on Monday. The Diamondbacks (12-13), who have scored a Major League-high 148 runs on the season, have won five of 12 road games on the year. The Cardinals (10-14) will be looking to avoid their second series loss in a row, after being swept by Milwaukee this past weekend. St. Louis has won nine of the past 15 games against Arizona.

The game is slated to begin at 1:15 p.m. ET from Busch Stadium in St. Louis. The Diamondbacks have the seventh-best team batting average at .255, while the Cardinals are 26th at .219. St. Louis is a -114 favorite on the money line in the latest Diamondbacks vs. Cardinals odds from SportsLine consensus, while the over-under for total runs scored is 8. Before making any Cardinals vs. Diamondbacks picks, be sure to see the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 5 of the 2024 MLB season on a profitable 110-85 run on top-rated MLB picks dating back to last season, and it has excelled on top-rated run-line picks during that span, going 19-7 (+737). Anybody following has seen huge returns.

Now, the model has set its sights on Cardinals vs. Diamondbacks and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model's picks. Here are several MLB odds and betting lines for Diamondbacks vs. Cardinals:

  • Diamondbacks vs. Cardinals money line: Arizona -105, St. Louis -114
  • Diamondbacks vs. Cardinals over/under: 8 runs
  • Diamondbacks vs. Cardinals run line: Arizona -1.5 (+157)
  • ARIZ: The Diamondbacks have hit the money line in 37 of their last 63 games (+11.20 units)
  • STL: The Cardinals have hit the game total under in 32 of their last 58 games (+5.80 units)
  • Diamondbacks vs. Cardinals picks: See picks at SportsLine

Why you should back the Diamondbacks

Left fielder Lourdes Gurriel Jr. has been on fire. In Tuesday's big win, he was 3-for-5 with a double and an RBI. He went 3-for-4 with a double in a 7-3 loss at San Francisco on Saturday. Over the last five games, Gurriel is 10-for-24 (.417) with two doubles and two RBI. In 23 games this season, he is hitting .300 with five doubles, five home runs, 22 RBI and 18 runs scored.

Right fielder Jake McCarthy has hits in seven of the past eight games, including at least one in each of the last four. In Tuesday's win, he was 2-for-4 with a walk and a run scored. He was 2-for-3 with a double, one RBI and one run scored in a 5-0 win over St. Louis on April 14. In 21 games this season, McCarthy is batting .300 with three doubles, six RBI and 12 runs scored. See which team to pick here

Why you should back the Cardinals

Right-hander Kyle Gibson will start for St. Louis. He has had two solid starts among his four on the season. In a 2-1 loss to the Milwaukee Brewers on Friday, he received a no-decision, going six innings and allowing three hits, one earned run, four walks and three strikeouts. In his first start of the season at San Diego on April 1, he picked up the win, pitching seven innings and allowing two earned runs, two walks and four strikeouts in a 6-2 win.

Shortstop Masyn Winn is off to a fast start to the season. In 22 games, he is batting .313 with three doubles, two triples, six RBI and eight runs scored. He has hits in six of his past 10 games, including a 2-for-3 performance with a double and a walk in a 3-1 win at Oakland on April 15. He was 2-for-4 with a triple, RBI and two runs scored in a 9-6 win at Arizona on April 12. See which team to pick here

How to make Cardinals vs. Diamondbacks picks

SportsLine's model is leaning Over on the total, projecting 9.1 combined runs. It also says one side of the money line has all the value. You can only get the model's MLB picks at SportsLine.

So who wins Diamondbacks vs. Cardinals, and which side of the money line should you back? Visit SportsLine now to see which side you need to jump on, all from the model that's 110-85 on top-rated MLB picks, and find out.