The 27-year-old goalie, whose brother Mike played for the Oilers from 2000-03, relished playing in goal in his hometown.
''It was great, but it's just two points and it doesn't matter who we're playing against and what's going on whether my family is in town,'' Comrie said. ''I'm just going out there with this group of guys and giving it all I have for this group, no matter where it is or when it is.
''Our D core did an awesome job of making sure everything was to the outside, everything was taken care of and props to them, they were awesome out there all night tonight.''
Rasmus Dahlin, Tage Thompson, Alex Tuch and J.J. Peterka scored for Buffalo. The Sabres improved to 2-1.
Dahlin joined Lindy Ruff as the second defenseman in franchise history to score in each of the first three games in a season.
''It wasn't pretty, but we found a way to win and that's what this league is all about,'' Dahlin said. ''We just dug in and played solid in the third period and he kept us in the game. It was a really good team effort and we have a lot of guys that come in here and compete hard, so it's really good for the future.''
Darnell Nurse and Ryan Nugent-Hopkins had goals for Oilers. They are 1-2.
''We don't want to be sitting at 1-2, but that being said, I don't think there's any need to panic,'' Oilers captain Connor McDavid said. ''This group knows how important starts are - not only to games, but to the season - and we haven't had our best for the first three. But I would expect our best is coming here.''
Buffalo took a 2-1 lead 46 seconds into the second period when Thompson danced around defenders and made a nice move at the net to slide the puck past goalie Stuart Skinner.
The Sabres made it 3-1 early in the second when Vinnie Hinostroza sprang Peterka for a breakaway and he put it through Skinner's legs.
Sabres: At Calgary on Thursday night.
Oilers: Host Carolina on Thursday night.
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