Offensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Quarterback | B. MayfieldBaker Mayfield | K. TraskKyle Trask | — |
| Running Back | R. WhiteRachaad White | S. TuckerSean Tucker | |
| Wide Receiver | M. EvansMike Evans | C. GodwinChris Godwin | |
| Tight End | C. OttonCade Otton | K. KieftKo Kieft | |
| Left Tackle | T. WirfsTristan Wirfs | J. SkuleJustin Skule | — |
| Left Guard | M. FeilerMatt Feiler | A. StinnieAaron Stinnie | — |
| Center | R. HainseyRobert Hainsey | N. LeverettNick Leverett | — |
| Right Guard | C. MauchCody Mauch | — | — |
| Right Tackle | L. GoedekeLuke Goedeke | B. WaltonBrandon Walton | — |
Defensive Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Left Defensive End | C. KanceyCalijah Kancey | M. GreeneMike Greene | |
| Nose Tackle | V. VeaVita Vea | G. GainesGreg Gaines | |
| Right Defensive End | L. HallLogan Hall | W. GholstonWilliam Gholston | — |
| Left Inside Linebacker | D. WhiteDevin White | K. BrittK.J. Britt | |
| Right Inside Linebacker | L. DavidLavonte David | S. DennisSirVocea Dennis | — |
| Strongside Linebacker | S. BarrettShaquil Barrett | A. NelsonAnthony Nelson | |
| Weakside Linebacker | J. Tryon-ShoyinkaJoe Tryon-Shoyinka | Y. DiabyYaYa Diaby | |
| Right Cornerback | C. DavisCarlton Davis | D. DelaneyDee Delaney | |
| Left Cornerback | J. DeanJamel Dean | C. IzienChristian Izien | |
| Strong Safety | R. NealRyan Neal | C. IzienChristian Izien | — |
| Free Safety | A. Winfield Jr.Antoine Winfield Jr. | K. MerriweatherKaevon Merriweather | — |
Special Teams Positions
| POS | Starter | Second | Third+ |
|---|---|---|---|
| Punter | J. CamardaJake Camarda | — | — |
| Kicker | C. McLaughlinChase McLaughlin | — | — |
| Long Snapper | Z. TrinerZach Triner | — | — |
| Holder | J. CamardaJake Camarda | — | — |
| Punt Returner | D. ThompkinsDeven Thompkins | T. PalmerTrey Palmer | — |
| Kick Returner | D. ThompkinsDeven Thompkins | R. WhiteRachaad White | — |