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Matt Ryan and the Indianapolis Colts are set to host Kenny Pickett and the Pittsburgh Steelers on Monday Night Football in the final game on the Week 12 NFL schedule. Both teams have relatively clean injury reports with defensive ends DeForest Buckner and Yannick Ngakoue are both questionable for Indianapolis, while running back Jaylen Warren is out for Pittsburgh. The latest Colts vs. Steelers odds suggest that this MNF game will be low-scoring with an over/under of 39.5 points, making it imperative to hit on the right mix of players from the MNF NFL DFS player pool when building your MNF NFL DFS strategy. Should Colts running back Jonathan Taylor, the reigning NFL rushing champion, be considered a must-start player in your NFL DFS lineups and NFL DFS stacks? Or would building around Michael Pittman Jr., Parris CampbellNajee Harris, Diontae Johnson, George Pickens, or Pat Freiermuth, who all project to be impact classic and showdown NFL DFS picks for Monday Night Football, be a better strategy?

Before making any NFL DFS picks for Colts vs. Steelers on sites like DraftKings and FanDuel, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings' NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor, who has been cashing big all season, has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.

Kaylor has been spot-on all season, hitting on epic NFL DFS picks like Jerry Jeudy (4-102-1), Stefon Diggs (12-148-3), Amari Cooper (7-101-1), Nick Chubb (23-113-1), CeeDee Lamb (8-87-1), Deebo Samuel (6-115-1) Cooper Kupp (14-122), Travis Kelce (7-25-4), Davante Adams (3-124-2), Justin Fields (179-1-1, 82-1), Diggs again in Week 8 (6-106-1), Chubb (23-101-2) and Cooper (5-131-1) again on MNF in Week 8, Kelce again in Week 9 SNF (10-106), Derrick Henry (132 total yards, 2 TDs) on Week 11 TNF, and Jimmy Garoppolo (228 yards, 4 TDs) on Week 11 MNF. Anyone who has followed his picks is way up.

Now, Kaylor has turned his attention to Colts vs. Steelers on Monday Night Football Week 12 and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.

Top NFL DFS picks for Colts vs. Steelers on MNF

One of Kaylor's favorite DFS picks for the Steelers vs. Colts matchup on MNF matchup is Indianapolis wide receiver Michael Pittman Jr.. With his impressive physical stature, the 2020 second round pick out of USC is a physical mismatch for most defensive backs. In 2022 he has emerged as Matt Ryan's unquestioned top target and has seen his target share increase under interim head coach Jeff Saturday. Since Saturday took over as Indianapolis' head coach, Pittman has been targeted 16 times, resulting in 13 catches for 128 yards. Kaylor expects that trend to continue, with Pittman having one of his most productive games of the season on Monday Night Football.

"Michael Pittman has an obvious chemistry with quarterback Matt Ryan and he has seen his role in the Indianapolis offense increase since Jeff Saturday took over as head coach. I expect that to continue on Monday night, when the Colts face the Steelers, who have one of the worst pass defenses in the league, allowing 272.1 yards per game through the air. I am projecting a floor of seven receptions for 85 yards for Pittman on MNF," Kaylor told SportsLine. You can see the rest of Kaylor's NFL DFS picks here.

How to build NFL DFS lineups for Steelers vs. Colts on MNF

Kaylor is also targeting another undervalued value who could explode for huge numbers for Monday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of Kaylor's MNF DFS picks, at SportsLine

So who is Jimmie Kaylor including in his optimal NFL DFS lineups for Monday Night Football? And which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a DFS expert who already won a single-game millionaire maker tournament in 2022, and find out.