San Diego acquired De Los Santos from the Guardians on Friday in exchange for Scott Barlow.
De Los Santos, 27, registered a sharp 3.18 ERA with 123 strikeouts over 119 innings during his two-year run in Cleveland. The right-hander logged 70 relief appearances in 2023 and could be a bullpen workhorse for the Padres next season.
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Guardians' Enyel De Los Santos: Emerges as reliable reliever
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De Los Santos finished the season tied for 18th in the majors with 70 appearances.
De Los Santos was a trusted part of the Guardians' bullpen throughout the year, though he wavered with a 5.59 ERA in September. He tossed a scoreless inning in Sunday's season-ending 5-2 loss to the Tigers. Overall, De Los Santos posted a 3.29 ERA, 1.14 WHIP and 62:25 K:BB over 65.2 innings while adding 16 holds, a 5-2 record and three blown saves. With Emmanuel Clase in place as closer, De Los Santos is unlikely to see ninth-inning assignments often as long as he remains with Cleveland.
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Guardians' Enyel De Los Santos: Picks up win in nightcap
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De Los Santos (5-2) struck out the only batter he faced and earned the win in Game 2 of Friday's doubleheader versus the Tigers.
De Los Santos got the last out in the top of the eighth inning, and the Guardians' offense rallied ahead in their half of the frame. He's allowed four runs over 6.2 innings in August, but he still has a solid 8:1 K:BB for the month, suggesting he's had a little bad luck. The right-hander is at a 2.84 ERA, 1.07 WHIP and 46:19 K:BB while adding 13 holds over 50.2 innings this year as part of the bridge to closer Emmanuel Clase.
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Guardians' Enyel De Los Santos: Takes loss Monday
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De Los Santos (4-2) allowed two runs on two hits in one inning to take the loss Monday versus the Blue Jays.
Starter Gavin Williams pitched seven innings of one-hit ball, but De Los Santos couldn't keep the momentum in Cleveland's favor, allowing a two-run home run to Cavan Biggio in the eighth. The homer ended a 10-inning scoreless streak for De Los Santos, who had a 9:3 K:BB with four holds in that span. The right-hander has emerged as a solid setup man for the Guardians with a 2.61 ERA, 1.01 WHIP and 42:18 K:BB over 48.1 innings while adding 11 holds this season. He slots in behind Emmanuel Clase and Trevor Stephan in the Guardians' late-inning mix.
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Guardians' Enyel De Los Santos: Collects fourth win
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De Los Santos (4-1) pitched a perfect inning to earn the extra-inning win over Atlanta on Tuesday.
De Los Santos worked the 10th inning and got some help on an outfield assist from Myles Straw to nab the potential go-ahead runner at the plate on a double play. David Fry then walked it off in the bottom of the 10th. De Los Santos has allowed just two hits while striking out five over his seven-inning scoreless streak. For the season, he's at a 2.57 ERA, 0.97 WHIP and 31:13 K:BB while adding six holds and a blown save over 35 innings. He's not firmly in the high-leverage mix, but he's pitched well enough to be trusted to protect leads.
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Guardians' Enyel De Los Santos: Secures extra-inning win
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De Los Santos (3-1) struck out one without giving up a hit or a walk in a scoreless inning to earn the extra-inning win over the Athletics on Tuesday.
De Los Santos pitched the 10th inning, and aside from a passed ball charged to catcher David Fry that moved the initial runner to third base, it was a sharp performance. Through eight appearances in June, De Los Santos has kept runs off the board five times, though a four-run meltdown versus the Red Sox on June 6 makes his numbers for the month look bad. He's been an effective middle reliever this year with a 3.10 ERA, 1.10 WHIP, 27:13 K:BB and four holds over 29 innings.
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Guardians' Enyel De Los Santos: Awful in first loss
Rotowire
De Los Santos (2-1) allowed four runs on two hits and two walks without recording an out to take the loss Tuesday versus the Red Sox.
De Los Santos also took a blown save for failing to protect a 2-1 lead in the eighth inning. It was easily his worst outing of the season -- he had a 6.2-inning scoreless streak from May 19 to June 3 and hadn't given up multiple runs in any appearance since April 9. The right-handed reliever still has a 3.52 ERA with a 1.13 WHIP, 18:10 K:BB and four holds over 23 innings this season. De Los Santos is likely to remain in a middle-reliever role.
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Guardians' Enyel De Los Santos: Nabs second win
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De Los Santos (2-0) earned the win Monday over the Yankees, recording two outs without allowing a baserunner.
De Los Santos got the last two outs of the eighth inning, picking off Anthony Volpe at first base and getting Anthony Rizzo to ground out after replacing starter Cal Quantrill. In the ninth, the Guardians rallied for the lead, and Emmanuel Clase was able to close it out. De Los Santos has given up just three runs (two earned) over 10.1 innings this season, good for a 1.74 ERA. He also has a 1.06 WHIP, 9:5 K:BB and a hold through 11 appearances. De Los Santos isn't likely to get many save chances, but he's holding his own while seeing some high-leverage opportunities.
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Guardians' Enyel De Los Santos: Back from paternity leave
Rotowire
De Los Santos was reinstated from the paternity list Friday, Tom Withers of the Associated Press reports.
After spending three days away from the team, the 27-year-old reliever is now back with the Guardians. De Los Santos holds a 1.35 ERA and 1.20 WHIP on the year across 6.2 innings, though he's made only one appearance since April 9.
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Guardians' Enyel De Los Santos: Goes on paternity leave
Rotowire
The Guardians placed De Los Santos on the paternity leave list Tuesday, Mandy Bell of MLB.com reports.
De Los Santos can be away for up to three days as he deals with much more important matters. He holds a 1.35 ERA over seven relief appearances this season.
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Guardians' Enyel De Los Santos: Earns extra-inning win
Rotowire
De Los Santos (1-0) struck out one in a perfect inning Sunday versus the Mariners, earning the extra-inning win.
De Los Santos worked the ninth inning of a 5-5 game, which was his third appearance of the young season. He's picked up a 3:1 K:BB over 2.2 hitless innings so far. The right-hander was mostly limited to middle-relief assignments in 2022, but he excelled in that role with a 3.04 ERA and 1.07 WHIP across 53.1 innings. He's unlikely to challenge for many saves with Emmanuel Clase, Trevor Stephan and James Karinchak in the high-leverage mix, but De Los Santos could be part of the bridge to get to the late innings.
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Guardians' Enyel De Los Santos: Ready to return
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De Los Santos is available to pitch Wednesday versus Team Mexico, Paul Hoynes of The Cleveland Plain Dealer reports.
De Los Santos was hampered by a hamstring issue early in spring training, but it appears he's moved beyond the injury. The right-hander will begin getting ready for the 2023 campaign. He is expected to fill a mid-leverage role in the bullpen after going 5-0 with a 3.04 ERA, 1.07 WHIP and 61:17 K:BB across 53.1 innings last season.
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Guardians' Enyel De Los Santos: Dealing with hamstring issue
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De Los Santos is dealing with a hamstring injury and may not be ready for Opening Day, Paul Hoynes of The Cleveland Plain Dealer reports.
De Los Santos has yet to make his Cactus League debut this spring, and the severity of his injury is unknown. The right-hander enjoyed the best season of his career in 2022 with a 3.04 ERA, 1.07 WHIP and 61:17 K:BB across 53.1 innings. If he can return to game action before the end of spring training, he should be considered likely to make the Opening Day roster.
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Guardians' Enyel De Los Santos: Secures fourth win
Rotowire
De Los Santos (4-0) struck out one in a perfect inning to earn the win Monday over the Angels.
De Los Santos worked the seventh inning and kept the game tied at 4-4 before Amed Rosario gave the Guardians a lead in their half of the frame. In his previous appearance, De Los Santos saw a nine-inning scoreless streak end when he allowed two runs in two-thirds of an inning versus the Twins on Friday. He's been an effective reliever this year, and he now owns a 2.91 ERA, 1.08 WHIP and 49:14 K:BB with one save and three holds through 46 innings.
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Guardians' Enyel De Los Santos: Picks up third win
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De Los Santos (3-0) struck out one and didn't allow a baserunner in two-thirds of an inning Thursday, earning the extra-inning win over the Tigers.
De Los Santos took a blown save for allowing an inherited runner to score the tying run on a fielder's choice in the ninth inning, but the Guardians regained the lead in the top of the 10th. The right-hander had been charged with one run in each of his three previous appearances. He's filled a middle-relief role for much of his time in the majors this year, pitching to a 3.22 ERA, 1.18 WHIP and 40:12 K:BB while adding a save and two holds through 36.1 innings.
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Guardians' Enyel De Los Santos: Covers two scoreless innings
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De Los Santos allowed two hits and struck out two over two scoreless innings versus the White Sox on Wednesday.
Aaron Civale (wrist) lasted only one inning in his start, making this an impromptu bullpen game for Clevland. De Los Santos did his part with his longest outing of the year, though he's routinely picked up four or five outs in appearances throughout 2022. The 26-year-old right-hander has pitched 3.1 consecutive scoreless innings and now sports a 3.25 ERA, 1.16 WHIP and 33:11 K:BB with one save and two holds through 27.2 innings.
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Guardians' Enyel De Los Santos: Clean inning Tuesday
Rotowire
De Los Santos struck out one in a perfect inning in Tuesday's 8-3 win over the Royals.
Since he was recalled from Triple-A Columbus on May 9, he's allowed just one hit and no walks with nine strikeouts across 7.1 scoreless innings. The right-hander is still seeing mostly low-leverage work, but he's done well to post a 2.08 ERA, 0.69 WHIP and 18:5 K:BB across 13 innings this season. He's also picked up a hold in 12 appearances.
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Guardians' Enyel De Los Santos: Back in majors
Rotowire
De Los Santos was brought up from Triple-A Columbus on Monday.
A number of scheduling changes saw the Guardians shuffle their pitching staff earlier this week. De Los Santos had previously been in the majors when a COVID-19 outbreak impacted the team before he was sent down. The right-hander will likely continue being used as a low-leverage bullpen arm.
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Guardians' Enyel De Los Santos: Returns to minors
Rotowire
The Guardians optioned De Los Santos to Triple-A Columbus on Sunday, Mandy Bell of MLB.com reports.
De Los Santos wasn't going to be available for Sunday's series finale with Toronto after he worked an inning and tossed 30 pitches while giving up a run and walking three in Saturday's 8-3 loss in Game 1 of a doubleheader. As a result, the Guardians will swap De Los Santos off the 26-man active roster for Kirk McCarty, who was called up from Triple-A in a corresponding move.
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Guardians' Enyel De Los Santos: Contract selected by Cleveland
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De Los Santos' contract was selected by the Guardians on Wednesday, Zack Meisel of The Athletic reports.
De Los Santos signed a minor-league deal with Cleveland in early December, but he'll now join the big-league club after several pitchers were placed on the injured list for an unspecified reason Wednesday. The right-hander has made four appearances at Triple-A Columbus to begin the year and has posted a 4.91 ERA and 1.64 WHIP in 3.2 innings.
