The New York Yankees attempt to extend their winning streak to six games when they visit the Seattle Mariners for the finale of their three-game series on Wednesday (9:40 p.m. ET). New York (34-23) endured a three-game skid before winning the final two contests of its three-game set against San Diego at home last weekend and taking the first two at Seattle. The Yankees' offense has been firing on all cylinders as the team has scored 10 runs in each of its last three outings. On Wednesday, New York's Clarke Schmidt (2-5, 5.58 ERA) takes the mound opposite Seattle's George Kirby (5-4, 3.43). The Mariners are -140 favorites (risk $140 to win $100) in the latest MLB odds from Caesars Sportsbook, while the Yankees are +118 underdogs. The over/under for total runs scored is 7.5.

The game is one of seven on the MLB schedule for Wednesday evening. Elsewhere in the majors, the Cincinnati Reds (+140) aim to match a season high with their fifth consecutive victory when they visit the Boston Red Sox and the Arizona Diamondbacks (-165) attempt to post their fourth win in a row when they host the Colorado Rockies. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons. It has opened the 2023 MLB season on a 29-20 roll on all-top rated MLB picks (+319). And on Monday, the model hit a Giants-Yankees-Dodgers parlay that paid almost 4-1. Anybody who has followed it has seen profitable returns. 

Now, the model has locked in three confident MLB best bets for Wednesday, all on games starting at 6:40 p.m. ET or later. If you successfully parlay the picks, you'd be looking at a payout of almost 5-1. You can only see the model's MLB picks at SportsLine

Top MLB picks today

After simulating every game on Wednesday 10,000 times, the model is picking the New York Mets (+100) to defeat the Philadelphia Phillies. After yielding 21 runs in back-to-back losses at Colorado, the Mets posted a 2-0 victory in the opener of this series on Tuesday. Right-hander Kodai Senga allowed one hit and struck out nine batters over seven innings and Francisco Lindor homered for the third time in four contests.

Pete Alonso, who leads the major leagues with 20 home runs, went 0-for-4 on Tuesday, but has prospered against Philadelphia starter Aaron Nola (4-3, 4.59) over his career. The 28-year-old Alonso has gone 15-for-43 (.349) with five blasts and 11 RBI versus the Phillies' ace. Mets right-hander Carlos Carrasco (1-2, 6.75) is 2-1 with a 4.02 ERA in four career games (two starts) against Philadelphia and is coming off his best outing of the season, a road victory over the Chicago Cubs in which he allowed one run and five hits over 6 2/3 innings. See who else to back here.

Featured Game | New York Mets vs. Philadelphia Phillies

How to make MLB parlays for Wednesday, May 31

The model has locked in two other best bets for Wednesday, including a team under .500 who pulls off a victory on the road. You can only see the model's MLB parlay picks and best bets at SportsLine

Which MLB picks should you target Wednesday for a shot at a return of nearly 5-1? Visit SportsLine now to see the MLB best bets for Wednesday from the model that is 29-20 on top-rated MLB picks this season, and find out.