It's time to decide who to start or sit in your Week 1 Fantasy football lineups. Dolphins vs. Chargers is the only game on the Week 1 NFL schedule with an over/under of at least 50 points. It's no surprise both teams are filled with players who will top the Week 1 Fantasy football rankings, but can you trust Tyreek Hill, Austik Ekeler, Justin Herbert, and Jaylen Waddle to carry your team to victory? Herbert is a comfortable start in the Week 1 Fantasy football QB rankings, but which Chargers pass-catchers will emerge? A reliable set of Week 1 Fantasy football rankings can help you figure out which matchups to target and how to optimize your season-long Fantasy football lineups. Before you lock in your Week 1 Fantasy football picks, be sure to check out the Week 1 Fantasy football rankings from the proven computer model at SportsLine.

The model is powered by the same people who generated projections for all three major Fantasy sites, and it beat human experts last season when there was a big difference in ranking. The 2023 Fantasy football PPR rankings and 2023 Fantasy football standard projections update multiple times daily, so you're always getting the best Fantasy football advice and the latest Fantasy football tiers.

Now, SportsLine has simulated the entire Week 1 NFL schedule 10,000 times and released its latest Week 1 Fantasy football rankings. Head to SportsLine now to see them

Top Week 1 Fantasy football QB rankings

Here's a look at SportsLine's top Week 1 Fantasy football QB picks: 

1. Lamar Jackson, Baltimore Ravens: Jackson dealt with multiple injuries last season, but he enters the 2023 NFL season healthy after signing a five-year, $260 million contract this offseason. Jackson has averaged 6.1 yards per carry thus far in his career and will try to exploit a Texans defense that gave up 379.5 yards per game last season, which ranked 30th.

2. Jalen Hurts, Philadelphia Eagles: Last season, Hurts finished with 760 yards and 13 rushing touchdowns. He's now recorded back-to-back seasons with at least 760 rushing yards and 10 rushing touchdowns. He also developed as a passer in 2022, finishing with 3,701 passing yards and 22 touchdowns, making him a no-brainer to include in your Week 1 Fantasy football lineups. See more top QBs here.

Top Week 1 Fantasy football RB rankings

Here's a look at SportsLine's top Week 1 Fantasy football RB picks: 

1. Austin Ekeler: He was the top-scorer in Fantasy football for non-quarterbacks last season and consistency was one of the biggest reasons why. He had at least 10 points in PPR formats the first 17 weeks, including nine weeks of more than 20. Ekeler was tied for fifth regardless of position in receptions (107) last season and should have another head-turning performance to begin the 2023 NFL season.

2. Tony Pollard: The Tony Pollard show is officially underway in Dallas. Even while splitting carries with Ezekiel Elliott last season, Pollard finished as RB8 in Fantasy football. That's with Elliott receiving 38 more carries and scoring 12 touchdowns. Now that Elliott's with the Patriots, Pollard is the No. 1 running back and will lead an offense that wants to run the football with head coach Mike McCarthy calling plays. Dallas wants to win by defense and time of possession and a Week 1 matchup with the Giants, who finished 31st in the NFL in yards allowed per carry (5.2) last season, on Sunday Night Football should be a Pollard coming-out party as an elite Fantasy football running back.

3. Bijan Robinson: Rookie running backs selected in the top 10 of the NFL Draft can offer a high return on investment for Fantasy football players. Saquon Barkley, the last running back selected inside the top 10 of the NFL Draft, rushed for 106 yards and a touchdown on 18 carries and had six targets in his debut. Expect a similar usage from Robinson in an Atlanta offense that averaged 4.9 yards per rush by its running backs last season. See more top RBs here.

Top Week 1 Fantasy football WR rankings

Here's a look at SportsLine's top Week 1 Fantasy football WR picks: 

1. Justin Jefferson: The Vikings wide receiver finished first in Fantasy points scored among wide receivers last year, despite scoring just eight touchdowns. Adam Thielen is no longer in the mix, giving Jefferson an even higher ceiling. He is facing a Tampa Bay defense that barely cracked the top 15 in scoring last year, so Jefferson's opportunities should be plentiful on Sunday.

2. Tyreek Hill: The former Kansas City star showed no signs of decline when he moved to Miami last year, finishing third among wide receivers in Fantasy scoring. He led the league in deep targets while scoring nine total touchdowns. Hill's target share (31.6%) ranked second in the NFL last year, and that volume makes him one of the top Fantasy wide receivers in Week 1.

3. Ja'Marr Chase: Cincinnati's wide receiver led all wide receivers in red-zone targets per game last year. That target share has led to 22 receiving touchdowns through his first two seasons in the league, and he plays in one of the top offenses in the NFL. Chase has a tough matchup against Cleveland's pass defense, which is why the model has him slotted behind Jefferson and Hill. See more top WRs here.

Top Week 1 Fantasy football TE rankings

Here's a look at SportsLine's top Week 1 Fantasy football TE picks:

1. Mark Andrews, Baltimore Ravens: With many moving parts in Baltimore, Andrews is the one constant for Lamar Jackson. That connection was evident last year when Andrews was the TE2 when Jackson was healthy in Weeks 1-12 but dropped to the TE21 over Weeks 13-18 when Jackson was sidelined. Andrews is the clear alpha at the position in Week 1 versus a Texans team that had an NFL-low three wins last year.

2. George Kittle, San Francisco 49ers: Kittle's numbers were down last year, but the most important stat, touchdowns, saw an increase. He developed a rapport with Brock Purdy and scored a career-high 11 touchdowns. Purdy and Kittle connected on seven scores over their last four regular-season games, so it's nearly impossible to keep someone on that kind of a run out of Week 1 Fantasy football lineups.

3. T.J. Hockenson, Minnesota Vikings: Hockenson never waits long to make his mark on an NFL season with his Week 1 performances. Over four career Week 1 games, he's averaged 80.5 receiving yards with three total touchdowns. Minnesota faces Tampa on Sunday, and just four teams allowed more touchdowns to tight ends last year than the nine the Bucs gave up. See more top TEs here.

Top Week 1 Fantasy football defense rankings 

Here's a look at SportsLine's top three Week 1 Fantasy football D/ST picks:

1. Saints D/ST: The Saints featured a top-five total defense last season, giving up an average of just 314.8 yards per game. New Orleans' Week 1 matchup is against the Tennessee Titans, who ranked 30th in total offense (296.8 ypg) in 2022.

2. Commanders D/ST: Washington's defense gave up 304.6 yards per game last season, the third-best mark in the NFL. On Sunday, the Commanders host the Arizona Cardinals, who are expected to start Joshua Dobbs at quarterback. Dobbs has only thrown 85 passes over six NFL seasons with the Steelers, Jags and Titans. 

3. Jaguars D/ST: The Jaguars made huge strides on defense in 2022 and now they'll face a rookie quarterback in Week 1. The Jags travel to play the Indianapolis Colts on Sunday with QB Anthony Richardson set to make his first start in the NFL. In addition, the Jags have held the Colts to 11 points or less in two of their last three meetings. See more top defenses here.

How to get Week 1 Fantasy football rankings

Now that you know who the top three at each position are, you'll want to see the full Week 1 Fantasy football rankings from SportsLine. The model has identified a stunner in the top five at quarterback, and knowing who it is can give you a huge edge in your league. Head to SportsLine now to get Week 1 Fantasy football rankings

So who should you target in your Week 1 Fantasy football rankings, and which surprising QB could lead you to victory? Visit SportsLine now to get Week 1 Fantasy Football rankings for every single position, all from the model that has a history of making league-winning calls, and find out.