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The No. 5 Ole Miss Rebels (2-0) will go on the road for the first time this season when they face the Wake Forest Demon Deacons (1-1) on Saturday night. Ole Miss is coming off blowout wins over Furman and Middle Tennessee, outscoring those opponents by a combined tally of 128-3. Wake Forest was on its way to a 2-0 start of its own, but it allowed 14 consecutive points in the fourth quarter of a 31-30 loss to Virginia. This is the first meeting between the Rebels and Demon Deacons since 2008. 

Kickoff is set for 6:30 p.m. ET on Saturday at Allegacy Federal Credit Union Stadium. Ole Miss is favored by 21.5 points in the latest Wake Forest vs. Ole Miss odds, while the over/under is 63.5 points, per SportsLine consensus. Before entering any Ole Miss vs. Wake Forest picks, you'll want to see the college football predictions from the model at SportsLine.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start on over/under picks this season. Anyone who has followed it has seen strong returns.

The model has set its sights on Ole Miss-Wake Forest. You can head to SportsLine to see its picks. Here are several college football betting lines for the game:

  • Wake Forest vs. Ole Miss spread: Ole Miss -21.5
  • Wake Forest vs. Ole Miss over/under: 64 points
  • Wake Forest vs. Ole Miss money line: Ole Miss -1887, Wake Forest +975
  • Wake Forest vs. Ole Miss picks: See picks here

Why Wake Forest can cover

Wake Forest led for most of its game against Virginia last week, but some untimely plays down the stretch led to a Cavaliers win. Transfer quarterback Hank Bachmeier became the starter last week after entering in relief in the opener. He has thrown for four touchdowns without an interception so far this season, and avoiding turnovers is one of the keys to springing an upset. 

Head coach Dave Clawson is 4-0 against SEC teams during his time at Wake Forest, and the Demon Deacons have won both of the previous meetings between these teams. Ole Miss is not only going on the road for the first time this season, but it is also facing a power-conference team for the first time. Wake Forest is 14-6 in its last 20 home games and is 9-3 in its last 12 games in September. See which team to pick here. 

Why Ole Miss can cover

Ole Miss has had this game circled on its calendar, as it is the school's only matchup against a power conference opponent during non-conference play. The Rebels have been very impressive through their first two games, blowing out both Furman and Middle Tennessee. Quarterback Jaxson Dart has established himself as an early Heisman Trophy candidate, coming up two completions shy of an NCAA record when he completed his first 24 throws against Middle Tennessee to set an SEC record. 

The Rebels have scored on 20 of their first 27 possessions this season, with 17 of those drives ending in touchdowns. Their defense has been equally impressive, as neither Furman not Middle Tennessee reached the 50-yard rushing mark. Ole Miss is 12-1 in its last 13 September games and has covered the spread in five of its last six games against ACC opponents. See which team to pick here. 

How to make Wake Forest vs. Ole Miss picks

The model has simulated Ole Miss vs. Wake Forest 10,000 times and the results are in. The model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 60% of simulations. You can only see the pick at SportsLine.

So who wins Wake Forest vs. Ole Miss, and which side of the spread is hitting well over 60% of the time? Visit SportsLine now to see which side of the Ole Miss vs. Wake Forest spread to jump on, all from the advanced computer model that's up over $2,000 on its top-rated college football spread picks since its inception, and find out.