A pair of blue-blood programs will square off in primetime when No. 9 Notre Dame hosts No. 6 Ohio State on Saturday night. The Fighting Irish have scored at least 40 points in their first four games of the season, including their 41-17 win over Central Michigan last week. They are facing an Ohio State defense that has allowed 20 total points this season. The Buckeyes cruised to a 41-10 victory when these teams met last year, winning for the fifth straight time in this series.

Kickoff is set for 7:30 p.m. ET at Notre Dame Stadium in Notre Dame. The latest Notre Dame vs. Ohio State odds via the SportsLine consensus list the Buckeyes as 3-point favorites, with the over/under at 55, which is up a point from the opener. Before locking in any Ohio State vs. Notre Dame picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed the model has seen huge returns.

Now, the model has set its sights on Notre Dame vs. Ohio State and just revealed its picks and predictions. You can visit SportsLine now to see the model's CFB picks. Here are several college football odds and trends for Ohio State vs. Notre Dame:

  • Ohio State vs. Notre Dame spread: Buckeyes -3
  • Ohio State vs. Notre Dame over/under: 55 points
  • Ohio State vs. Notre Dame money line: Buckeyes -165, Fighting Irish +140
  • OSU: Ten of last 13 Ohio State games have gone Over the total
  • ND: 3-1 ATS this season
  • Ohio State vs. Notre Dame picks: See picks at SportsLine
  • Ohio State vs. Notre Dame live stream: fubo (try for free)

Why Ohio State can cover

Junior quarterback Kyle McCord continues to play well for the Buckeyes. McCord has a great touch on his deep passes with a lightning-quick release. McCord has thrown for 815 yards and six passing touchdowns. On Sept. 16 against Western Kentucky, he went 19 of 23 for 318 yards and three passing scores. This was his second consecutive game with three passing touchdowns.

Junior running back TreVeyon Henderson is the main option in the backfield. Henderson climbs to the second level with ease and has the quickness to break away. He currently has 30 carries for 191 yards and four touchdowns. The Virginia native is also averaging 6.4 yards per rush. In Week 3, Henderson had 88 rush yards and two scores. Senior running back Chip Trayanum changes the pace and adds power to the ground game. Trayanum is second on the team in carries (19) and rush yards (133). He's notched at least 50 rush yards in two of the last three games. See which team to pick here.

Why Notre Dame can cover

Notre Dame's offense has been on fire with quarterback Sam Hartman under center, scoring at least 40 points in each of its first four games. Hartman's 13 touchdown passes are a school record for most touchdown passes in the first four games of a season. He jumped to seventh on major college football's career touchdown passes list when he threw three touchdowns last week, with two of those scoring strikes being 75-plus yards.

The Fighting Irish have an improved rushing attack this year as well, averaging more than 200 yards per game after Audric Estime finished with 176 yards last week. They have covered the spread in four of their last five games and are 5-1-1 against the spread in their last seven games against Big Ten opponents. Ohio State has only covered three times in its last nine contests, including a 1-4 mark in its last five games as a favorite. See which team to pick here.

How to make Notre Dame vs. Ohio State picks

SportsLine's model is leaning Over on the point total, projecting the teams to combine for 56 points. The model also says one side of the spread hits nearly 60% of the time. You can see the model's picks at SportsLine

So who wins Ohio State vs. Notre Dame, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has notched a profit of almost $2,500 on its top-rated college football spread picks, and find out.