The No. 17 Duke Blue Devils will try to make their second major statement of the season when they host the No. 11 Notre Dame Fighting Irish on Saturday night. Duke opened the year with a 28-7 win over then-No. 9 Clemson, and it has added a trio of blowout wins since then. Notre Dame is coming off a 17-14 heartbreaking loss to then-No. 6 Ohio State, as the Buckeyes scored the game-winning touchdown with one second remaining. The Fighting Irish picked up a 27-13 victory when these teams last met, but that game was played in 2020.

Kickoff at Wallace Wade Stadium is set for 7:30 p.m. ET. SportsLine consensus lists the Fighting Irish as 5.5-point favorites, up one point from the opening line, in the latest Duke vs. Notre Dame odds, with the over/under at 53 points. Before making any Notre Dame vs. Duke picks or bets, be sure to check out the college football predictions and betting advice from SportsLine football expert Jimmie Kaylor

Kaylor is a NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. 

Kaylor has been red-hot on his football picks this season for SportsLine, posting a 9-2 record thus far, including a 4-1 mark last Saturday. Anyone who has followed his picks is way up.

Now, he has set his sights on Notre Dame vs. Duke and just locked in its picks and CFB predictions. You can head to SportsLine now to see Kaylor's picks. Here are several college football odds and betting lines for Duke vs. Notre Dame:

  • Duke vs. Notre Dame spread: Notre Dame -5.5
  • Duke vs. Notre Dame over/under: 53 points
  • Duke vs. Notre Dame money line: Notre Dame -217, Duke +178
  • ND: QB Sam Hartman has 14 TD passes in 2023.
  • DUKE: QB Riley Leonard is averaging 59.5 rushing yards per game in 2023.
  • Duke vs. Notre Dame picks: See picks at SportsLine
  • Duke vs. Notre Dame live stream: fubo (try for free)

Why Notre Dame can cover

Notre Dame returned 15 starters off last year's 9-4 team. The Irish have one of the premier offensive lines in college football, and have the talent to take control of this game at the line of scrimmage. Leading the way for Notre Dame is Audric Estime, who has 77 carries for 591 yards and five touchdowns in 2023.

Notre Dame also has one of the most prolific quarterbacks in the country in Sam Hartman, a transfer from Wake Forest. Hartman enters this matchup with 1,236 passing yards, 14 touchdown passes and zero interceptions for the season. In his career, the sixth-year senior has 14,203 passing yards (ninth most in college football history), 124 TD passes (seventh most in college football history) and 19 rushing touchdowns. See which team to pick at SportsLine

Why Duke can cover

Duke has won six straight games since the end of last season, covering the spread five times while springing a pair of outright upsets. One of those wins came as a 12-point home underdog against Clemson to open the season, as the Blue Devils forced three turnovers and scored three rushing touchdowns. They have won their first four games by an average margin of victory of 28.5 points per game, ranked fourth nationally in scoring defense.

Notre Dame's offense was largely contained by Ohio State last week, and Duke's elite defense will be playing in front of a loud home crowd. Offensively, Blue Devils quarterback Riley Leonard has done an excellent job of managing games, passing for 778 yards, two touchdowns and zero interceptions. Duke is 10-1 in its last 11 September games, and it has covered the spread in seven of its last nine games against FBS Independent opponents. See which team to back at SportsLine

How to make Duke vs. Notre Dame picks

Kaylor has analyzed this matchup from every angle and he's leaning Under on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins Duke vs. Notre Dame on Saturday, and which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see Notre Dame vs. Duke picks, all from the expert who has covered college football for over a decade and is 9-2 on his best bets in 2023, and find out.