ACC programs meet in prime time for the first of four FBS matchups on the Friday night college football schedule. The NC State Wolfpack welcome the Louisville Cardinals to Carter-Finley Stadium in Raleigh for the fifth game of the 2023 season on both sides. NC State is 3-1 overall and 1-1 in ACC play this season. Louisville enters at 4-0 overall and 2-0 against ACC opponents, with six wins in the last seven contests against conference foes.

SportsLine consensus lists the Cardinals as 3-point favorites for this 7 p.m. ET kickoff. The total number of points Vegas thinks will be scored, or the over/under, is 56 in the latest Louisville vs. NC State odds. Before locking in any NC State vs. Louisville picks, you need to see the college football predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, the proprietary computer model has generated a stunning profit of almost $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed the model has seen huge returns.

Now, the model has set its sights on Louisville vs. NC State and just revealed its picks and predictions. You can visit SportsLine now to see the model's CFB picks. Here are several college football odds and trends for NC State vs. Louisville:

  • Louisville vs. NC State spread: Louisville -3.5
  • Louisville vs. NC State over/under: 56 points
  • Louisville vs. NC State money line: Louisville -177, NC State +149
  • LOU: The Cardinals are 10-7 against the spread in the last 17 games
  • NCSU: The Wolfpack are 4-13 against the spread in the last 17 games
  • Louisville vs. NC State picks: See picks at SportsLine
  • Louisville vs. NC State live stream: fubo (try for free) 

Why Louisville can cover

Louisville's undefeated start is led by the program's robust offense, but the defense is also playing well to begin the 2023 season. The Cardinals are allowing only 19 points per game, a top-four mark in the ACC, and Louisville is allowing a 55.8% completion rate to opponents. Louisville is giving up only 3.6 yards per rush attempt, and the Cardinals are in the top 10 of FBS in red-zone efficiency allowed (55.6%) this season. 

NC State has the second-fewest passing yards in the ACC so far this season, and this could be a friendly matchup for the Louisville defense. On offense, Louisville leads the ACC in total yards (542.0 per game), passing yards (304.8 per game), and rushing yards (237.3 per game) this season, and the Cardinals are putting up 6.0 yards per rush attempt. Louisville is in the top five nationally with 7.7 yards per play, and last week's explosion of 56 points is a positive indicator for the Cardinals. See which team to pick here.

Why NC State can cover

NC State's defense is stout this season. The Wolfpack are in the top 15 of FBS in third down efficiency allowed (30.0%), with NC State allowing only 326.0 total yards per game. Opponents are averaging only 114.5 rushing yards per game and 3.7 yards per carry against NC State, and the Wolfpack are allowing a meager 58.1% completion rate to opposing passing games. Senior linebacker Payton Wilson leads the ACC with 46 tackles, a figure that also ranks No. 8 in all of FBS, and Wilson has more than 300 tackles in his college career. 

On offense, Brennan Armstrong leads a group that is averaging 29.3 points per game. Armstrong arrives from Virginia as an accomplished transfer, and he holds program records at his previous school in passing yards and passing touchdowns. NC State is also converting almost 52% of third down chances, ranking in the top three of the ACC, and the Wolfpack are 19-3 in the last 22 games in Raleigh. See which time to pick here.

How to make NC State vs. Louisville picks

SportsLine's model is leaning Under on the point total, projecting 55 combined points. The model also says one side of the spread hits well over 50% of the time. You can see the model's picks at SportsLine

So who wins Louisville vs. NC State, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has notched a profit of almost $2,500 on its top-rated college football spread picks, and find out.