The Vanderbilt Commodores will return home on Saturday afternoon when they host the Kentucky Wildcats in an SEC East battle. Vanderbilt picked up wins over Hawaii and Alabama A&M in its first two games before losing back-to-back road games against Wake Forest and UNLV. Kentucky is getting set for its first road game after beating Ball State, Eastern Kentucky and Akron. The Wildcats suffered a 24-21 loss to Vanderbilt last season, snapping a six-game winning streak in the series. 

Kickoff is set for noon ET on Saturday at FirstBank Stadium in Nashville. The Wildcats are favored by 14 points in the latest Vanderbilt vs. Kentucky odds, while the over/under is set at 50.5 points, per SportsLine consensus. Before entering any Kentucky vs. Vanderbilt picks, you'll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Since its inception, it has generated a stunning profit of nearly $2,500 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

The model has set its sights on Kentucky vs. Vanderbilt. You can head to SportsLine to see its picks. Here are several college football betting lines for Vanderbilt vs. Kentucky:

  • Vanderbilt vs. Kentucky spread: Kentucky -14
  • Vanderbilt vs. Kentucky over/under: 50.5 points
  • Vanderbilt vs. Kentucky money line: Vanderbilt: +419, Kentucky: -573
  • Vanderbilt vs. Kentucky picks: See picks here
  • Vanderbilt vs. Kentucky live stream: fubo (try for free)

Why Vanderbilt can cover

Vanderbilt stunned Kentucky last season, pulling off a 24-21 upset as a 17-point road underdog. The Commodores rushed for 264 yards and racked up 448 total yards, overcoming a pair of turnovers in the upset. They have now covered the spread in four of the last five head-to-head meetings between these teams. 

The Commodores got off to a strong start at home, beating Hawaii and Alabama A&M, and they will be happy to return to FirstBank Stadium on Saturday. They led UNLV 17-0 last week, but four turnovers were ultimately too much to overcome. Wide receivers Will Sheppard, Jayden McGowan and London Humphreys have combined for 875 of Vanderbilt's 1,155 receiving yards this season. 

Why Kentucky can cover

Kentucky has been dominant to open the season, cruising to blowout wins over Ball State, Eastern Michigan and Akron. Quarterback Devin Leary has connected for more than 100 yards with five different players, while running back Ray Davis has tallied 379 yards from scrimmage. Davis was at Vanderbilt in 2021 and 2022, rushing 26 times for 129 yards and a touchdown in the game between these teams last season. 

The Commodores have struggled without Davis, finishing with just 83 yards on 38 rushing attempts in last week's loss to UNLV. Their defense has been equally as bad, allowing an average of 389 yards and 29.2 points per game. They have failed to cover the spread in five straight games overall and seven of their last eight home games, while Kentucky has covered in four of its last six games. See which team to pick here. 

How to make Vanderbilt vs. Kentucky picks

The model has simulated Kentucky vs. Vanderbilt 10,000 times and the results are in. The model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You can only see the pick at SportsLine.

So who wins Vanderbilt vs. Kentucky, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Kentucky vs. Vanderbilt spread to jump on, all from the advanced computer model that's up nearly $2,500 on its top-rated college football spread picks since its inception, and find out.