Cal Poly trailed 17-0 late in the second quarter and by 27-14 with 12:11 left in the fourth. Ryan Rivera's 10-yard score with 7:30 left pulled the Mustangs within 27-21 and Coleman's 35-yarder capped the scoring at 2:20.
Brian Dukes sealed it for Cal Poly on an interception with 1:22 left.
Coleman had a game-high nine catches for 94 yards for Cal Poly (1-1). Josh Cuevas and Tyrece Fairly-Diyem each had a touchdown catch.
Judd Erickson was intercepted three times for San Diego (1-1). Re-al Mitchell was 2-of-4 passing for 30 yards and two touchdowns.
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